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Cured: How the Berlin Patients Defeated HIV and Forever Changed Medical Science

Cured: How the Berlin Patients Defeated HIV and Forever Changed Medical Science

by Nathalia Holt

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Overview

Is the end of HIV upon us? Award-winning research scientist and HIV fellow at the Ragon Institute, Nathalia Holt, reveals the science behind the discovery of a functional cure and what it means for the millions affected by HIV and the history of the AIDS pandemic.

Two men, known in medical journals as the Berlin Patients, revealed answers to a functional cure for HIV. Their cures came twelve years apart, the first in 1996 and the second in 2008. Each received his own very different treatment in Berlin, Germany, and each result spurred a new field of investigation, fueling innovative lines of research and sparking hope for the thirty-four million people currently infected with HIV. For the first time, Nathalia Holt, who has participated in some of the most fruitful research in the field, tells the story of how we came to arrive at this astounding and controversial turning point.

Holt explores the two men’s stories on a personal level, looking at how their experiences have influenced HIV researchers worldwide—including one very special young family doctor who took the time to look closely at his patients—and how they responded to their medications.

Based on extensive interviews with the patients and their doctors as well as her own in-depth research, this book is an unprecedented look at how scientists pursue their inquiries, the human impact their research has, and what is and is not working in the relationship between Big Pharma and medical care.

Product Details

ISBN-13: 9780525953920
Publisher: Penguin Publishing Group
Publication date: 02/27/2014
Pages: 336
Sales rank: 1,026,420
Product dimensions: 5.90(w) x 9.10(h) x 1.30(d)
Age Range: 18 Years

About the Author

NATHALIA HOLT, PhD, is an HIV fellow at the Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University. She has devoted her career to the cutting edge of HIV research and therapy. She lives in Boston with her family.

Table of Contents

Cast of Characters xi

Preface xiii

Part I A Doctor, Two Patients, and Some Tests

Chapter 1 The Good Doctor in Denial 3

Chapter 2 A Visit with the Family Doctor 13

Chapter 3 Death Sentence? 21

Part II The Disease, a Drug, and Its Industry

Chapter 4 Viral Trojan Horse 33

Chapter 5 A Weapon from the War on Cancer 43

Chapter 6 The Days of Acting Up 57

Chapter 7 Recognizing a Global Pandemic 65

Chapter 8 From the One Percent 79

Chapter 9 But, Doctor, I Don't Feel Sick 87

Chapter 10 The Delta 32 Mutation 95

Chapter 11 Calling All Elite Controllers 99

Chapter 12 Treatment in Hiding 111

Part III Treating the Berlin Patients

Chapter 13 The Second Diagnosis 119

Chapter 14 The Compassionate Use Exemption 131

Chapter 15 Three Deadly Diseases Move In 135

Chapter 16 The Comfort of Family and Strangers 141

Chapter 17 Timing 147

Chapter 18 Transplanting 153

Chapter 19 "Perhaps We Have Eradicated HIV" 163

Chapter 20 An Unexciting Recovery 175

Part IV The Cure

Chapter 21 Trials 185

Chapter 22 Proof of Principle 199

Chapter 23 The Good Doctor in Court 205

Chapter 24 Not Even Surprising 209

Chapter 25 The Promise Kept 221

Chapter 26 A Child Cured-So What? 241

Chapter 27 Zinc Finger Snap 249

Chapter 28 The Abused, the Respected, the Relentless 261

Notes 273

Timeline 297

Acknowledgments 299

Index 303

What People are Saying About This

From the Publisher

“I am eagerly anticipating Nathalia Holt’s telling of the Berlin Patients and the implications of their apparent cure from HIV infection.”
—David Baltimore, Nobel Laureate for Medicine, professor of Biology, and former president, California Institute of Technology

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