Cutaneous Neuroimmunomodulation : The Proopiomelanocortin System

Cutaneous Neuroimmunomodulation : The Proopiomelanocortin System

by Thomas A. Luger

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Product Details

ISBN-13: 9781573312011
Publisher: New York Academy of Sciences
Publication date: 10/01/1999
Series: Annals of the New York Academy of Scienc
Pages: 479

Table of Contents

The Proopiomelanocortin System in Cutaneous Neuroimmunomodulation: An Introductory Overviewxi
Part I.Extracutaneous Proopiomelanocortin Biology
The Proopiomelanocortin System1
POMC-Derived Peptides and Their Biological Action22
The Pituitary-Skin Connection in Amphibians: Reciprocal Regulation of Melanotrope Cells and Dermal Melanocytes41
The Subtilisin/Kexin Family of Precursor Convertases: Emphasis on PC1, PC2/7B2, POMC and the Novel Enzyme SKI-157
The Role of Melanocortins in Adipocyte Function75
An Immunocytochemical Approach to the Study of [beta]-Endorphin Production in Human Keratinocytes using Confocal Microscopy85
Part II.The Melanocortin Receptors
UV Light and MSH Receptors100
The Melanocortin-1 Receptor and Human Pigmentation117
Genetic Studies of the Human Melanocortin-1 Receptor134
Molecular Pharmacology of Agouti Protein in Vitro and in Vivo143
Synthetic Melanocortin Receptor Agonists and Antagonists153
Proopiomelanocortin and the Immune-Neuroendocrine Connection161
Part III.Proopiomelanocortin and the Skin Immune System: Modulation of the Immune Response
Mechanisms of Antiinflammatory Action of [alpha]-MSH Peptides: In Vivo and in Vitro Evidence173
[alpha]-MSH in Systemic Inflammation: Central and Peripheral Actions183
Human Peripheral Blood-Derived Dendritic Cells Express Functional Melanocortin Receptor MC-1R188
Neural Influences on Induction of Contact Hypersensitivity196
Role of Epidermal Cell-Derived [alpha]-Melanocyte Stimulating Hormone in Ultraviolet Light Mediated Local Immunosuppression209
Part IV.Modulation of Skin Physiology by Proopiomelanocortin Products
[alpha]-MSH and the Regulation of Melanocyte Function217
Molecular Basis of the [alpha]-MSH/IL-1 Antagonism230
Expression of Functional Melanocortin Receptors and Proopiomelanocortin Peptides by Human Dermal Microvascular Endothelial Cells239
Mechanisms of the Antiinflammatory Effects of [alpha]-MSH: Role of Transcription Factor NF-[kappa]B and Adhesion Molecule Expression254
POMC and Fibroblast Biology262
The Role of Proopiomelanocortin-Derived Peptides in Skin Fibroblast and Mast Cell Functions268
Alpha-Melanocyte-Stimulating Hormone Modulates Activation of NF-[kappa]B and AP-1 and Secretion of Interleukin-8 in Human Dermal Fibroblasts277
Part V.Corticotropin-Releasing Hormone-Proopiomelanocortin Interactions
Cutaneous Expression of CRH and CRH-R: Is There a "Skin Stress Response System?"287
Corticotropin Releasing Factor Receptors and Their Ligand Family312
Part VI.Proopiomelanocortin-Peptides--Clinical Relevance
[alpha]-MSH Can Control the Essential Cofactor 6-Tetrahydrobiopterin in Melanogenesis329
Melanocortins and the Treatment of Nervous System Disease: Potential Relevance to the Skin342
The Skin POMC System (SPS): Leads and Lessons from the Hair Follicle350
Part VII.Poster Papers
Expression of MC1- and MC5-Receptors on the Human Mast Cell Line HMC-1364
Characterization of [mu]-Opiate Receptor in Human Epidermis and Keratinocytes368
Characterization of a Polyclonal Antibody Raised Against the Human Melanocortin-1 Receptor372
Effects of Ethanol Consumption on [beta]-Endorphin Levels and Natural Killer Cell Activity in Rats383
Murine Dendritic Cells Express Functional Delta-Type Opioid Receptors387
Expression of Corticotropin Releasing Hormone in Malignant Melanoma391
Depression Modulates Pruritus Perception: A Study of Pruritus in Psoriasis, Atopic Dermatitis and Chronic Idiopathic Urticaria394
[alpha]-MSH Immunomodulation Acts via Rel/NF-[kappa]B in Cutaneous and Ocular Melanocytes and in Melanoma Cells396
Microinjection of Alpha-MSH Followed by UV-Irradiation Blocks HSP 72 in Human Keratinocytes400
[beta]-Endorphin Binding and Regulation of Cytokine Expression in Langerhans Cells405
[alpha]-MSH Reduces Vasculitis in the Local Shwartzman Reaction414
Implications of the Phenotype of POMC Deficiency for the Role of POMC-Derived Peptides in Skin Physiology419
Serotonin in Human Allergic Contact Dermatitis422
Differential Temporal and Spatial Expression of POMC mRNA and of the Production of POMC Peptides During the Murine Hair Cycle427
Effective Treatment of Pruritus with Naltrexone, an Orally Active Opiate Antagonist430
Developmentally Regulated Expression of [alpha]-MSH and MC-1 Receptor in C57BL/6 Mouse Skin Suggests Functions Beyond Pigmentation433
Plasma [beta]-Endorphin Concentrations During Natural and Artificially Induced Winter Hair Growth in Mink (Mustela vison)440
Expression of Proopiomelanocortin Peptides and Prohormone Convertases by Human Dermal Microvascular Endothelial Cells444
ACTH Production in C57BL/6 Mouse Skin448
Coexpression of Nitric Oxide Synthase and POMC Peptides in the Dystrophic C57BL/6J Mouse451
Ligand Binding Profile and Effects of Melanin-Concentrating Hormone on Fish and Mammalian Skin Cells455
Occurrence of Four MSHs in Dogfish POMC and Their Immunomodulating Effects459
Specific Binding Sites for [beta]-Endorphin on Keratinocytes464
Skin POMC Peptides: Their Binding Affinities and Activation of the Human MC1 Receptor466
The Expression of [alpha]-MSH by Melanocytes Is Reduced in Vitiligo470
[alpha]-MSH Inhibits Lipopolysaccharide Induced Nitric Oxide Production in B16 Mouse Melanoma Cells474
Index of Contributors477

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