Cytochrome P450: Structure, Mechanism, and Biochemistry / Edition 4

by Paul R. Ortiz de Montellano

Overview

This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cyhrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cyhrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems.

Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cyhrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cyhrome P450 inhibition. Two more chapters discuss the nature and roles of cyhrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cyhrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.

Product Details

ISBN-13:	9783319374376
Publisher:	Springer International Publishing
Publication date:	11/18/2016
Edition description:	Softcover reprint of the original 4th ed. 2015
Pages:	912
Product dimensions:	7.01(w) x 10.00(h) x 0.07(d)

About the Author

Paul R. Ortiz de Montellano received his PhD in bioorganic chemistry from Harvard University, Cambridge, MA. After postdoctoral work as a North Atlantic Treaty Organization Fellow in Zürich, Switzerland, and a stint with Syntex in Mexico City and Palo Alto, California, he joined the faculty of the University of California in San Francisco, where he is currently Professor, Vice-chair of the Department of Pharmaceutical Chemistry, and Associate Dean for Research of the School of Pharmacy. His research interests center on the structure, mechanism, inhibition, and biochemistry of hemoproteins, including the cyhrome P450 enzymes. He has received the B.B. Brodie Award in Drug Metabolism from the American Society of Pharmacology and Experimental Therapeutics, the R.T. Williams Distinguished Scientific Achievement Award from the International Society for the Study of Xenobiotics, and the Ernest H. Volwiler Research Achievement Award from the American Association of Colleges of Pharmacy.

Table of Contents

.- Volume 1

.- 1 Structures of Cyhrome P450 Enzymes

.- 2 Electron Transfer Partners of Cyhrome P450

.- 3 Activation of Molecular Oxygen in Cyhromes P450

.- 4 Substrate Oxidation by Cyhrome P450 Enzymes

.- 5 Inhibition of Cyhrome P450 Enzymes

.- 6 Microbial Cyhromes P450

.- 7 P450s in Plants, Insects and their Fungal Pathogens

.- 8 P450 Biotechnology

.- Volume 2

.- 9 Human Cyhrome P450 Enzymes

.- 10 Nuclear Receptor-Mediated Regulation of Cyhrome P450 Genes

.- 11 Hormonal Regulation of Liver Cyhrome P450 Enzymes

.- 12 P450 Enzymes in Steroid Processing

.- 13 P450 Enzymes in Lipid Oxidation.

Editorial Reviews

4 Stars! from Doody

Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This book, a third edition, provides comprehensive coverage of cytochrome P450. A particular asset is the extensive bibliography provided for each chapter. Previous editions were published 10 and 20 years ago.
Purpose: The goal is to provide updated information on all aspects of cytochrome P450. Given the importance of this family of proteins in many areas of metabolism, this is highly worthwhile. The book succeeds well.
Audience: Material in this book will serve a broad audience: advanced students, fellows, and senior investigators. Those not working in the area will also find material of interest, particularly on mechanism of action and breadth.
Features: In the 10 years since the previous edition of this book was published, much new material has been developed, mechanisms better understood, and the diversity of the P450 family better defined. Hence the impetus for a new look. Material covered in this edition includes a section on mechanism, cosubstrates (the reducing partners), oxygen management, plant and bacterial sources, and a comprehensive article on human variants. The latter is particularly distinguished by exhaustive coverage and an impressive bibliography; this feature alone makes this edition a worthwhile investment. The editor has assembled an excellent group of contributors and maintained high standards throughout. The importance of this family of proteins in the metabolism of externally acquired materials (mainly organics and including most drugs) is well developed. The genetic aspects are also discussed with specific inductions a focus. Research laboratories in both academic and drug company settings will find much useful material here.
Assessment: An impressive achievement. The 1,500 references in the chapter on human P450 (a small book in itself) are a major asset. Even individuals far removed (scientifically) will find material of interest. Certainly all students and fellows working in this area will want a copy.

Doody's Review Service

Praise for the Second Edition: ‘Professor Paul R. Ortiz de Montellano (known in some databases as 'P.R.O. Demontellano' has spared no effort in the preparation of this major work. All 15 chapters and the two appendices were written by experts of high international reputation. The content is structured into four parts arranged clearly and logically. As a result, the reader goes from the table of contents to the main body of the book with a favourable impression of clarity and comprehensiveness. Needless to say, this impression is verified throughout the chapters.'
ISSX: International Society for Study of Xenobiotics (October 1996)
‘The 1986 edition of Cyhrome P450: Structure, Mechanism, and Biochemistry is probably the most frequently cited single source of information about the subject...Ortiz de Montellano has now produced a second edition with 15 new chapters. In my estimation, he has again succeeded in bringing the P450 field into sharp focus.'
Science, 271 (March 1996)

From the Publisher