This book describes procedures for and results of applying the technique of targeted gene disruption (knockouts) to questions of the biological function(s) of cytokines. The editors state that this book will provide the reader with a comprehensive understanding that gene knockout experiments have played in illuminating the wide range of critical biological activities of cytokines in an organism. This is a very worthy objective and it is well received. This book is primarily written for researchers in the field, but will be of interest to anyone who wishes to appreciate the power of the modern technique of gene knockout research. The editors are acknowledged experts in the field. Illustrations are not critical to the subject matter of this book. The book is well referenced and has a good table of contents and index. It is attractive, easy to read, and well produced. This book is a very nice compendium of research in a very important area -- the biological function of cytokines and the considerable advances in this field brought about by gene knockout techniques. It may not serve the needs of researchers actively involved in this field, since it covers so much material in such a short volume, but because of its scope it should be interesting and useful to researchers inside and outside the field. It should be on the shelves of all life science/biomedical libraries. Researchers in the field may wish to own their own copy of this book.
Compiles recent information on a research method in immunology that involve switching off various cytokine genes in mice, and watching the physiological consequences of the deficiency in that particular cytokine. The 24 studies, many reporting the author's own research, relate the phenotypes to other knockout mice and to human diseases. They identify potential targets for new drugs; demonstrate the unique role of each cytokine in health and disease; highlight unresolved questions such as missing cytokines and receptors and biochemical pathways; and provide insights into the pathogenesis and treatment of arthritis and sepsis. The effects they discuss range from diseases of the bowel, lung, heart, blood, kidney, and liver to immune deficiency, developmental defects, and autoimmunity. Annotation c. by Book News, Inc., Portland, Or.