D-type Cyclins and Cancer

D-type Cyclins and Cancer

Paperback(Softcover reprint of the original 1st ed. 2018)

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Product Details

ISBN-13: 9783319877976
Publisher: Springer International Publishing
Publication date: 06/20/2018
Series: Current Cancer Research
Edition description: Softcover reprint of the original 1st ed. 2018
Pages: 152
Product dimensions: 6.10(w) x 9.25(h) x (d)

About the Author

Philip W. Hinds is Professor and Chair of the Department of Developmental, Molecular and Chemical Biology at Tufts University School of Medicine. He is also the Deputy Director of Tufts Medical Cancer Center. Dr. Hinds is an expert in cell cycle control and its dysregulation in cancer cells. He participates in several journal editorial boards including the Journal of Biological Chemistry, the Chinese Journal of Cancer, and Cancer Research to name a few.

Nelson E. Brown is currentlyAssociateProfessor at theUniversity of Talca School of Medicine in Chile. He is also Director of the Center for Medical Research at the University of Talca.​His currentwork focuses on the role of cyclin D1-associated kinase activityin senescence and tumorigenesis

Table of Contents

The D-type Cyclins: A Historical Perspective.- Mammalian Development and Cancer – A Brief History of Mice Lacking D-type Cyclins or Cdk4/6.- D-type Cyclins and Gene Transcription.- Splice Variants and Phosphorylated Isoforms of Cyclin D1 in Tumorigenesis.- Cyclin D1, Metabolism, and the Autophagy-Senescence Balance.- Shifting a Paradigm: Cyclin D Activates pRb by Mono-Phosphorylation.

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