This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the “retinoblastoma pathway” to incorporate new evidence that suggests that cyclin D1’s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discriminationof target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases.
About the Author
Philip W. Hinds is Professor and Chair of the Department of Developmental, Molecular and Chemical Biology at Tufts University School of Medicine. He is also the Deputy Director of Tufts Medical Cancer Center. Dr. Hinds is an expert in cell cycle control and its dysregulation in cancer cells. He participates in several journal editorial boards including the Journal of Biological Chemistry, the Chinese Journal of Cancer, and Cancer Research to name a few.
Nelson E. Brown is currentlyAssociateProfessor at theUniversity of Talca School of Medicine in Chile. He is also Director of the Center for Medical Research at the University of Talca.His currentwork focuses on the role of cyclin D1-associated kinase activityin senescence and tumorigenesis
Table of ContentsThe D-type Cyclins: A Historical Perspective.- Mammalian Development and Cancer – A Brief History of Mice Lacking D-type Cyclins or Cdk4/6.- D-type Cyclins and Gene Transcription.- Splice Variants and Phosphorylated Isoforms of Cyclin D1 in Tumorigenesis.- Cyclin D1, Metabolism, and the Autophagy-Senescence Balance.- Shifting a Paradigm: Cyclin D Activates pRb by Mono-Phosphorylation.