Life is getting strange in Twombly, Illinois.
Jairus Twombly's familial gift of intuition is faltering and his new personal assistant seems to be trying to replace his wife, Amy.
On the Twombly College campus, someone is breaking into the dorm rooms of female students to leave red colored objects including a red golf ball, a red ribbon and a tiny red stuffed dog.
When a recipient of some of the red objects goes missing and is released after being told, "You're not her", and the personal assistant turns up dead with Amy Twombly's elegant crochet hook in her eye, things heat up for Emory Crawford and her chemistry professor and forensic scientist husband, Dr. Jebbin Crawford. When Amy Twombly is arrested for the murder, the police seem sure of her guilt. Emory vows to find the real killer before Amy goes to prison for a crime Emory is sure she did not commit. And who is the strange stalker who loves red? What will happen when he finds the 'right' victim?
Emory, along with the Twombly's Nancy Drew-like daughter, Madison, once more turns to her amateur Miss Marple style detective skills and intuition to solve the mysteries.