Dementia and Aging Handbook

Brain aging is a complex natural process characterized by the aging of brain proteins and acquisition of toxicity. It begins early in life and escalates with age. Brain protein aging includes a broad range of processes of protein modifications such as phosphorylation, protein structural changes, glycation, methylation, protein-protein and protein-RNA interaction, common and rare variant transition, and the gain of toxic function. Brain aging gradually leads to neurodegeneration and memory l...