The Demon under the Microscope: From Battlefield Hospitals to Nazi Labs, One Doctor's Heroic Search for the World's First Miracle Drug

The Demon under the Microscope: From Battlefield Hospitals to Nazi Labs, One Doctor's Heroic Search for the World's First Miracle Drug

by Thomas Hager


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In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of sulfa, the first antibiotic and the drug that shaped modern medicine.

The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness.

A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel.

Product Details

ISBN-13: 9781400082148
Publisher: Crown/Archetype
Publication date: 08/28/2007
Edition description: Reprint
Pages: 352
Sales rank: 294,414
Product dimensions: 5.22(w) x 8.00(h) x 0.76(d)

About the Author

Veteran science and medical writer Thomas Hager is the author of three books, including Force of Nature: The Life of Linus Pauling, and his work has appeared in publications ranging from Reader’s Digest to Medical Tribune. A former director of the University of Oregon Press, contributing editor to American Health, and correspondent for the Journal of the American Medical Association, he lives in Eugene, Oregon.

Read an Excerpt

Chapter One Gerhard Domagk looked at the blood soaking his tunic. It was 1914, a few days before Christmas. The German army had just finished an artillery barrage. Domagk's unit had been sent in, the young men and their officers walking slowly through the yellowing grass toward a Polish farmhouse, their breath showing white, when shots came from somewhere to their left. Domagk saw the officer nearest him fall. Then he felt a blow to his head. His helmet flew off and landed somewhere in the grass. His chest felt hot. When he looked down, he saw the blood. He had attended a single term of medical school before joining the army and knew enough to give himself a quick exam. He found no wound on his body. Then he discovered the source. Blood was streaming from his head, down his neck, and onto his shirt. He explored his scalp gently with his fingers. Hard to say how bad the gash was, but it had probably opened when the bullet knocked his helmet off. He bandaged himself with a large handkerchief. Then he passed out. When he awoke, he was jolting through trees in a farmer's cart toward what had been a church, now a German field hospital, where he was examined, his bleeding stopped, and his wound dressed. When the staff decided that it appeared likely he would survive, he was packed onto a train to Berlin, to recuperate in a central hospital. The wound did not look serious, but there was no way to know if there would be permanent brain damage. Time would tell. The blow to his head did not change Domagk's mind about the war. He, like most of his fellow university students, had been infected and rendered mildly delirious during the epidemic of patriotic fever that swept Germany in the summer of 1914. The tall, thin boy volunteered for service with more than a dozen of his classmates and friends soon after war was declared. They were inducted as a group into the Leibgrenadier Regiment of Frankfort on the Oder, a unit specializing in the use of grenades. They were given a few weeks of cursory training. Then they were loaded onto a train for Flanders. They were young and full of energy, eager to join Germany's march, giddy with visions of a short, glorious war. Domagk, the son of a village schoolmaster, was eighteen years old and ready for adventure. He was also a young gentleman who brought his lute to training camp and played folk tunes around the campfire. He wanted to take the instrument with him to the front. When his officers told him that regulations forbade it, he dismantled it, sent the body back to his parents, and kept the neck attached to his knapsack as a memento. Inside the knapsack he carried a photo of his village sweetheart dressed in her white Communion gown. Now, months later, he was beginning to miss his home, Lagow in the lake country of far eastern Germany. Picturesque and quiet, Lagow became the source of ever-sunnier memories the longer he spent in the army: cannonballing into the river below the mill; a swarm of children flying out of school at the end of the day; a group of friends concocting homemade gunpowder; sneaking his first cigar; the taste of a ripe pear in late summer. He spent his nineteenth birthday in the trenches of Flanders under fire from British ships, huddled in the dirt, "the heavens lit," he wrote his parents, "from burning villages." The glory of war began to fade. He and his comrades were soaked by freezing autumn rains, exhausted, starving, their uniforms caked with muck. Once while digging for drinking water, they broke open an abscess in the earth, a cache of rotting French soldiers, men killed and buried, he figured, by his own unit's grenades. The Germans were dug in near the Belgian coastal town of Nieuport, where in late October the Leibgrenadier Regiment of Frankfort on the Oder was ordered to participate in a massive attack. Their officers told them that following a 4:00 a.m. German artillery barrage they would charge forward from their trenches and drive the enemy from their trenches. The young men synchronized their watches. They wrote last letters home and put them in their pockets, promising each other that the living would deliver them for the dead. They waited for what seemed a very long time in the dark, listening to shells screaming overhead, watching the flashes. When the barrage stopped, the young German soldiers struggled and slipped out of their holes. They slogged through a football field's length of mud before they started falling, then heard the chattering of machine guns at short range, each one firing as many bullets as 250 rifle-equipped soldiers. Most of the boys Domagk had joined with were dead within a few seconds. The rest ran. Domagk later figured that only he and two or three others out of his group of fifteen student volunteers survived the battle alive and unwounded. They learned later that their charge was part of a huge failed offensive in which the Germans lost 135,000 soldiers, many of them recent university students, in the course of four weeks of fierce fighting. The British called it the First Battle of Ypres. The Germans called it Kindermord: "The Massacre of the Innocents." Too ripped up to fight any longer in Flanders, Domagk and what remained of the Leibgrenadiers were transferred to the Eastern Front. A few weeks later, he lost his helmet near the Polish farmhouse. When he began to gather his senses about him in a Berlin hospital room, he discovered that his knapsack was gone, along with the neck of his lute and the photo of his sweetheart. All he now had of his childhood were memories. He remembered his father sitting at the window, waiting for the lamp man. The gas streetlights in Lagow were lit every evening by the lamp man, who came came by with his white horse. Then one day the man stopped coming. When Gerhard's father explained to him that the lamp man had been delayed because his horse was sick, the young boy was stricken by the idea. "I said at the end of the evening prayer with my mother, 'Good God, please make the lamp man come again,'" he remembered. "'Make his horse better again.' " The German army hospital administration in Berlin, on reviewing their records, found that wounded Leibgrenadier Gerhard Domagk had attended a bit of medical school. It was decided that rather than send him back to the front lines, they would set him to the task of providing medical care for the wounded. Domagk was placed in a training program for medical assistants, one of hundreds of novices hastily pressed into service. After a few weeks of first-aid training, he was sent back to the Eastern Front, through Krakow to a field hospital in the Ukraine. He was fascinated by his trip through "the culture of the East," as he called it, the lands of Germany's destiny, the "beautiful but dirty streets," the Jews with "caftans reaching over their long boots and their corkscrew-like curls hanging down from their temples." He was especially impressed by the architecture he saw. Flanders had been bad, but the Eastern Front was in many ways worse, especially when it came to medical care. The German casualties were just as heavy, but the hospitals were cruder, doctors fewer, supplies scarcer. The field hospital to which Domagk was assigned was stark, a farm in the middle of the woods roughly converted into a care facility with tents for wards and a barn for an operating room. Every day a miscellany of ambulances, cars, trucks, and farm carts arrived, disgorged their loads of quiet, white-faced wounded, and left for more. There was a constant, deep rumble from big guns a few miles away. They were seeing wounds no one had ever seen before, thanks to the advance of military and industrial science. Newly deployed and unprecedentedly powerful weapons—artillery that could shoot shells 120 kilometers, high-explosive shells like the giant "Jack Johnsons" that geysered black earth a hundred feet in the air, airplanes and aerial bombs, tanks and poison gas—were slaughtering men at a rate and in ways unimaginable a few years earlier. In previous wars men had been shot or stabbed. Now they were blown to bits. The new weapons changed both the manner of fighting—more trenches, fewer cavalry charges—and what happened after. Because of the new weapons, the number of dead and wounded on both sides was staggering. During the entire Franco-Prussian War in the 1870s, a total of a quarter of a million men were killed and wounded on both sides over ten months of battle—roughly the same total number of killed and wounded at the First Battle of Ypres alone. Military leaders realized within a few months of the war's start that they needed to quickly expand their medical services. Anyone with any medical ability was pressed into service in the rapidly growing network of hospitals. That was how Domagk ended up in the woods of the Ukraine. One of his jobs was to sort the new arrivals, separating the obvious infectious cases, cholera especially, and moving them out of camp as quickly as possible; setting aside those whose wounds were least severe, those with the best chance of recovery, and sending them immediately into the queue for surgery; then arranging for the remainder, the severely wounded, those with parts of their heads blown away, the cases with burst intestines, those no longer responsive. The worst were put under the straw. Comforted as much as possible, of course, given water, told their turn would come, to keep up their spirits, that the straw would keep them warm. They were generally in shock anyway, pulses thready, color graying, skin growing cold. They would last a night or two at most. Another of his jobs was to go out in the morning, pull the straw away, and make a final sorting. The living were reexamined. The dead went into that day's mass grave. With the grisly morning chore out of the way, aides like Domagk were often given strip-and-clean duty. The wounded arrived filthy, their shredded uniforms crusted with dried blood and dirt. Some had been wounded for days, lying in water pooled in the bottom of bomb craters. Many were infested with lice. The young aides cut away the uniforms, peeled them off and burned them, then tried to wash the men as well as they could, working around the open wounds and broken bones. Most of the men were surprisingly silent and stoic, showing their strength. Others moaned or sometimes screamed. That done, Domagk was often called to help in the operating room. The surgeons worked in shifts twenty-four hours a day, the operating theaters in the barn, lit with hissing carbide lamps at night, or in tents. Everything was in short supply—morphine, anesthetic, sterilization equipment, surgical instruments. It was impossible to keep the area clean. Gowning and masking were rare; assistants like Domagk worked bare-handed in their uniforms. "We could hardly keep the flies away," he remembered. All the medical staff were dizzy from exhaustion and from breathing the ether and chloroform they dripped onto pads and held over the mouths and noses of the wounded. The physicians and aides fled the operating areas whenever they could, napping outside even in the rain to get away from the insects and the fumes. Get what sleep you can; sort the new arrivals; strip and clean; pull the bodies from the straw; assist in surgery; fall into bed; get what sleep you can; sort the new arrivals. . . . This was Domagk's life for two years. He was smart, young, and strong, he followed orders and worked hard. He earned a reputation as a reliable, steady man. And he was unusually observant. Some people had a feeling for medicine, a caring personality, or—like the surgeons—a combination of hand-eye coordination and steady nerves. Domagk had the ability to see. He watched everything, noted slight variations, quietly filed it all away. He witnessed more operations in two years than many surgeons see in a lifetime; helped set compound fractures, the bones bristling through the skin; used magnets to search for pieces of shrapnel; watched the surgeons run their fingers down the insides of intestines, probing for holes; assisted with countless amputations; threw the severed arms and legs onto a growing pile in a side room. The physicians came to trust him as he spent more and more time in the operating room. Domagk for his part came to have a profound respect for what could be learned by cutting through the skin. He saw what lay beneath, saw what could be fixed with knives and thread and what could not. He saw that surgery could sometimes work miracles, and he learned about other things in medicine that did not work. Infectious disease was the bane of every military facility. Cholera was an especially severe problem in close-packed military camps. Around a campfire one evening, an old officer serving in Domagk's hospital told the young assistants about an epidemic of cholera that had raced through Hamburg fifteen years earlier, killing thousands in the city; a terrible disease, he said, the man still unsettled by the scope and swiftness of the contagion he had witnessed. He then told the young aides a bit of folk wisdom: Alcohol, he said, generously imbibed, could ward off cholera. The only thing they had in camp, apart from the pure alcohol sequestered to clean wounds, was red wine, so all the young men started drinking as much as they could get. Then, a few evenings after he was told the story, Domagk remembered, the old officer started complaining of a pain in his calves. A few hours after that, the older man was dead—from cholera. Folk wisdom, Domagk learned, was little protection against disease. The most important thing that Domagk observed in the Ukraine was that even the most heroic and seemingly successful surgeries could go completely wrong a few days later. A soldier could wake one morning to find his carefully closed incisions, which had been fine the day before, now swollen, red, and painful. The edges, perhaps, had started to split open. Sometimes a foul-smelling, dark liquid oozed out. The skin around the wound began to take on a "a curious half-jellified, half-mummified look," as one physician described it. These were signs of what military physicians feared most in their postoperative cases: Gasbrand, the Germans called it. Gas gangrene. The doctors knew what caused Gasbrand—an infection by bacteria—and they knew how it progressed, the microscopic invaders eating away and essentially rotting the muscle tissue, releasing as they went both toxins that poisoned the patient and a gas that ballooned his wounds.

What People are Saying About This

From the Publisher

“Fascinating . . . A rousing, valuable contribution to the history of medicine.”
-Kirkus Reviews (Starred)

"A well-told tale of trail-blazing science."

"Highly recommended."
-Library Science

"This is a grand story, and Mr. Hager tells it can easily imagine 'The Demon Under the Microscope,' like 'Microbe Hunters' before it, inspiring in young, idealistic readers the enthusiasm for medical research and the zeal for healing that generates great physicians."
-Wall Street Journal

"Surprisingly entertaining...[Hager's] enthusiasm for the search for a 'magic bullet' drug in the early 20th century is infectious. He convincingly credits sulfa drugs for some of the most revolutionary and catastrophic moments in medicine. And anecdotes about famous people affected- from Calvin Coolidge to Eleanor Roosevelt- are narrative spoonfuls of sugar."
-Entertainment Weekly

"Grips the reader from the first paragraph...a story of dedication, luck, tragedy and triumph that's still relevant today."

"Hager, a biographer of Linus Pauling, does a remarkable job of transforming material fit for a graduate biology seminar into highly entertaining reading. He knows that lay readers need plenty of personality and local color, and his story is rich with both. This yarn prefigures the modern rush for corporate pharma patents; it is testament to Hager's skills that the inherently unsexy process of finding the chemicals that might help conquer strep is as exciting an account of the hunt for a Russian submarine."
-Publishers Weekly

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Demon under the Microscope: From Battlefield Hospitals to Nazi Labs, One Doctor's Heroic Search for the World's First Miracle Drug 4.3 out of 5 based on 0 ratings. 14 reviews.
civiwarlibrarian More than 1 year ago
Thomas Hager opens Demon Under The Microscope with compelling descriptions of December 7 1941's wounded and those who cared for them. The setting is Tripler General Hospital in Hawaii. Ambulances, trucks, and cars bring the torn, the lacerated, and the roasted to the hospital. When it is filled the lawns of the facility are covered with the injured. The hospital's three operating rooms are in service for nearly a full day. Surprisingly and quite unlike World War One, there is not a single death from infection. In the first three chapters, Hager weaves stories of battlefield medicine from before the discovery from the French Revolution to World War One. The science of bacteriology began immediately before and during the First World War in which soldiers living in earthworks and trenches could die and without even be wounded. It was a world without antibiotics. In Germany, Gerhard Domagk and his colleagues at Bayer Corporation worked constantly to identify which microscopic bacteria caused tuberculosis, malaria, and blood poisoning. Discovered in 1932, sulfa became the first of the modern antibiotics. Hager addresses the biology and chemistry of the discovery through the competitive personalities, the national environments, and the aggressive international marketplace. Patent wars, lawsuits, dying children of U.S. Presidents, a nearly dead Winston Churchill after the Teheran Conference move the story forward. Research chemists, laboratory mice, and fortunate and unfortunate accidents may be mundane, but not when the Nazi's are looking over shoulders and monitoring research labs. Nazi chieftan Reinhard Heydrich was wounded by Czech assassins and, due to a possible misuse of sulfa, dies. To find out if sulfa was the cause, Ravenbruck concentration camp's laboratory conducts infection and sulfa studies on women prisoners. For those who have seen Saving Private Ryan, recall the episode where the medic is wounded in the assault on the Nazi communication post. He wound was dusted with white powder, a sulfa drug. Demon Under the Microscope is a well paced, personality driven suspense story of scientific discovery. There are no photographs in the book; it would have been enhanced by portraits of the main characters. On the other hand, your mind supplies the visuals from Hager's descriptions.
sciencenerd88 More than 1 year ago
Rather than provide a synopsis, I'll simply say that it provides a wonderful backbone from which to construct an understanding on early 20th century Biology and Medicine, as well as the marriage and honeymoon on these two philosophies.
samayatara More than 1 year ago
This is not just a book about science, it is also about history; the history of war, politics, countries, culture, law, and medicine. Although chock full of names, events, and dates, Demon under the Microscope is surprisingly well organized and easy to follow. When I bought this book I thought it was about the discovery penicillin, I was wrong. I did not know anything about the important drug discoveries that took place before the invention of penicillin. I learned so much from this book that helped me to better understand current events and drug products: for example, where Bayer Aspirin came from, why the FDA is so careful about testing new drugs, how "Big Pharma" got started, why there are strict guidelines for advertising natural/homeopathic products, the importance of a double blind study, in some cases I learned that "some things never change." I highly recommend this book. It is a fascinating story.
kaelirenee on LibraryThing More than 1 year ago
For most of human history, microbial infections meant deformity, long-term illness, and often death. Queen Victoria almost died because of a boil, FDR, Jr. of a sinus infection. Alchemists, midwives, and scientists have been trying to find ways of treating these illnesses. But finding something that could kill an infection without also killing the host is difficult. Even after discovering how infections were spread, it wasn¿t possible to stop an infection. Lister¿s solutions to sterilize operating rooms were wonderful, but could never be taken internally without causing excruciating pain.Hager takes the reader on the history of the first real triumph in antibiotics-sulfa drugs. This story spans 4 countries, two World Wars, and touches the lives of several heads of state. It includes everything necessary for a good coming-of-age novel, including a poor and struggling scientist still getting over the horrors of his time in combat, scientists snagging ideas from each other and learning things by accident, and several near-death experiences. This is not some boring scientific tome devoted to the chemical properties of chemotherapeutic medicines. It is the very human story of what drove dozens of scientists, several corporations, and governments to find drugs that seriously changed how infection was viewed on the battlefield. Hager displays several vignettes to demonstrate the path that sulfa drugs took from dye to medicine, and then to near-irrelevance. This is an excellent account that explains how the new kind of pharmaceutical research started. The early 20th century showed a new direction for scientific research. Instead of the dedicated, philanthropic, hobbyist scientist happening upon discoveries (a la Louis Pasteur), companies formed with the goal of discovering chemicals that could be created, patented, and sold at huge profits. If they saved lives, all the better. And because of this trend, government regulation became a necessity. The FDA¿s history is presented as well, including the cases that allowed it to gain more prominence and hold more power to regulate the patent medicine market.This book reads like a novel that travels from the germ theory of disease to penicillin resistance, leaving the reader with a better understanding of how scientific endeavors are taken on and of many of the struggles and obstacles facing pharmaceutical researchers-and the people waiting for cures.
mauveberry on LibraryThing More than 1 year ago
The title isn't very clear, but this book is about the story of sulfa, the first antibiotic that was discovered. Not only does the book talk about how scientists discovered sulfa, but the book also talks about how it influenced the way that drugs are regulated, the nature of pharmaceutical companies, and the way that doctors work. There were some short comments in the book that made me feel that the author did know what it's like to work in the laboratory, and that made me appreciate the book.The thing I didn't like about the book was that it didn't seem very organized and kind of jumped around. Otherwise, the history was interesting. I had not known that antibiotics existed before penicillin.
Anonymous More than 1 year ago
Thomas Hager story detailing the history of sulfa was intriguing and quite interesting when you contrast modern medicine today and the variety of antibiotics available and used to treat diseases. The advent of sulfa played a significant role in saving lives during WWII, as well as, lives among the wartime civilians. Hager also describes the the development of and formation of the FDA and the importance government oversight has in the manufacture and testing of new drugs. Sulfa at the time was seen as a miracle drug, when you consider the deaths associated with what we refer too today as the common sore throat. It is unfathomable to imagine today, deaths associated with streptococcus, although they do occur or the thought of sinus infection protentially being life threatening as was the case with Roosevelts son.
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