Design and Analysis of Vaccine Studies / Edition 1 available in Hardcover
- Pub. Date:
- Springer New York
This book is intended for colleagues and students in statistics, biostatistics, epidemiology, and infectious diseases. Most essential concepts are described in simple language accessible to epidemiologists, followed by technical material accessible to statisticians.
M. Elizabeth Halloran and Ira Longini are professors of biostatistics at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle. Claudio Struchiner is professor of epidemiology and biostatistics at the Brazilian School of Public Health of the Oswaldo Cruz Foundation in Rio de Janeiro. The authors are prominent researchers in the area. Halloran and Struchiner developed the study designs for dependent happenings to delineate indirect, total, and overall effects. Halloran has made contributions at the interface of epidemiological methods, causal inference, and transmission dynamics. Longini works in the area of stochastic processes applied to epidemiological infectious disease problems, specializing in the mathematical and statistical theory of epidemics. Struchiner has contributed to understanding the role of transmission in interpreting vaccine effects.
Table of ContentsIntroduction and examples.- Overview of vaccine effects and study designs.- Immunology and early phase trials.- binomial and stochastic transmission models.- R0 and deterministic models.- Evaluating protective effects of vaccination.- Modes of action and time-varying VES.- Further Evaluation of Protective Effects.- Vaccine effects on post-infection outcomes.- House-hold based studies.- Analysis of households in communities.- Analysis of independent households.- Assessing Indirect, total and overall effects.- Randomization and baseline transmission.- Surrogates of protection.