Pub. Date:
Taylor & Francis
Design of Caspase Inhibitors as Potential Clinical Agents / Edition 1

Design of Caspase Inhibitors as Potential Clinical Agents / Edition 1

by Tom O'Brien, Steven D. Linton


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Product Details

ISBN-13: 9781420045406
Publisher: Taylor & Francis
Publication date: 10/28/2008
Series: Enzyme Inhibitors Series
Pages: 312
Product dimensions: 6.30(w) x 9.30(h) x 0.90(d)

Table of Contents

Mammalian Caspase Activation Pathways in Apoptosis and Inflammation, S.E. Logue and S.J. Martin

Role of Caspases in Inflammation-Driven Diseases, K. Kersse, T.V. Berghe, S. Lippens, W. Declercq, and P. Vandenabeele

Role of Caspases in Apoptotic-Driven Indications, T. Matsui

Kinetics and Catalytic Activity of Caspases, K.A. Nalley

Nonpeptide Small Molecule Inhibitors of Caspases, A. V. Ivachtchenko, I. Okun, S.E. Tkachenko, A.S. Kiselyov, Y.A. Ivanenkov, and K.V. Balakin

Identification of Inflammatory Caspase Inhibitors, J.A. Wos and T.P. Demuth Jr.

Identification of Apoptotic Caspase Inhibitors, B.R. Ullman

Discovery of a First-in-Class Apoptotic Caspase Inhibitor Emricasan (PF-03491390/IDN-6556), N.C. Hoglen

Novel Approaches to Caspase Inhibitor Discovery, J.M. Scheer and M.J. Romanowski

Therapeutic Potential for Caspase Inhibitors: Present and Future, H. Eda


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From the Publisher

... can be a valuable reference source for scientist and students dealing with the medicinal chemistry and chemical biology aspects of apoptosis, inflammation and related diseases.
—Dr. Enrique Pérez-Payá, Centro de Investigación Príncipe Felipe and CSIC (Spain) in ChemMedChem 2009

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