ISBN-10:
9048198798
ISBN-13:
9789048198795
Pub. Date:
11/04/2010
Publisher:
Springer Netherlands
Detection of Biological Agents for the Prevention of Bioterrorism / Edition 1

Detection of Biological Agents for the Prevention of Bioterrorism / Edition 1

by Joseph Banoub
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Overview

The threat of biological and chemical terrorism has driven the demand for timely techniques that can quickly detect the agent or agents used in an attack. The detection and/or prevention of these potential security threats provide significant scientific and technical challenges due to the combination of possible agents and modes of delivery available.
This book will present a thorough look at the importance and technological challenges of mass spectrometry (MS) for the detection & identification of biological and chemical threats. This new contribution’s general aims are to draw the attention of recognized practitioners, experts and graduate students trying to grasp the latest MS developments in the cutting-edge fields of MS-biodefense technologies for the rapid/early/specific sensitive threat detection of pathogens, viruses, explosives, mycotoxins, chemical agents, and biological markers of xenobiotic chemicals.

Product Details

ISBN-13: 9789048198795
Publisher: Springer Netherlands
Publication date: 11/04/2010
Series: NATO Science for Peace and Security Series A: Chemistry and Biology
Edition description: 2011
Pages: 360
Product dimensions: 5.90(w) x 9.00(h) x 0.90(d)

Table of Contents

Preface vii

Broadband Analysis of Bioagents by Mass Spectrometry Catherine Fenselau Colin Wynne Nathan Edwards 1

Hollow-Fiber Flow Field-Flow Fractionation for Mass Spectrometry: From Proteins to Whole Bacteria Pierluigi Reschiglian Andrea Zattoni Diana Cristina Rambaldi Aldo Roda Myeong Hee Moon 13

Mass Spectrometry and Tandem Mass Spectrometry for Protein Biomarker Discovery and Bacterial Speciation Alvin Fox Karen Fox 37

Intact Cell/Spore Mass Spectrometry of Fusarium Macro Conidia for Fast Isolate and Species Differentiation Hongjuan Dong Martina Marchetti-Deschmann Wolfgang Winkler Hans Lohninger Guenter Allmaier 47

Bacteriophage Amplification-Coupled Detection and Identification of Bacterial Pathogens Christopher R. Cox Kent J. Voorhees 65

Matrix Assisted Laser Desorption Ionization Mass Spectrometric Analysis of Bacillus anthracis: From Fingerprint Analysis of the Bacterium to Quantification of its Toxins in Clinical Samples Adrian R. Woolfitt Anne E. Boyer Conrad P. Quinn Alex R. Hoffmaster Thomas R. Kozel Barun K. De Maribel Gallegos Hercules Moura James L. Pirkle John R. Barr 83

Microorganism Identification Based On MALDI-TOF-MS Fingerprints Thomas Elssner Markus Kostrzewa Thomas Maier Gary Kruppa 99

Mass Spectrometric Detection of Botulinum Neurotoxin by Measuring its Activity in Serum and Milk Suzanne R. Kalb James L. Pirkle John R. Barr 115

Functional Assays for Ricin Detection Eric Ezan Elodie Duriez François Fenaille François Becher 131

Challenges of Detecting Bioterrorism Agents in Complex Matrices Erica M. Hartmann Rolf U. Halden 149

DESI-MS/MS of Chemical Warfare Agents and Related Compounds Paul A. D'Agostino 163

Mass Spectrometry Applications for the Identification and Quantitation of Biomarkers Resulting from Human Exposure to Chemical Warfare Agents J. Richard Smith Benedict R. Capacio 181

Applications of Mass Spectrometry in Investigations of Alleged Use of Chemical Warfare Agents Robert W. Read 201

Mass Spectrometry for the Analysis of Low Explosives Bruce McCord Megan Bottegal John Mathis 221

Identification of the Bacterial Cellular Lipid Fraction by Using Fast GC x GC-MS and Innovative MS Libraries Luigi Mondello Peter Quinto Tranchida Giorgia Purcaro Chiara Fanali Paola Dugo Erminia La Camera Carlo Bisignano 231

Endotoxins in Environmental and Clinical Samples Assessed by GC - Tandem MS Bogumila Szponar 245

Imaging Mass Spectrometry Michelle L. Reyzer Richard M. Caprioli 267

2 and 3D TOF-SIMS Imaging for Biological Analysis John S. Fletcher 285

Application of Mass Spectrometry for the Analysis of Vitellogenin, a Unique Biomarker for Xenobiotic Compounds Alejandro M. Cohen Joseph H. Banoub 301

Mass Spectrometry as a Powerful Analytical Technique for the Structural Characterization of Synthesized and Natural Products Nour-Eddine Es-Safi El Mokhtar Essassi Mohamed Massoui Joseph Banoub 319

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