This comprehensive study of the developmental biology of the ocular lens will serve as a reference for graduate students and research scientists in the visual sciences and developmental biology, as well as for ophthalmologists. Clarification of the mechanisms that govern normal lens development is fundamental to our understanding of lens disorders. The lens has also become a model for studying more complex organ systems. Leading experts in lens development and structure discuss lens induction, evolution, cell cycle regulation, morphology, fiber cell differentiation, and regeneration.
|Publisher:||Cambridge University Press|
|Product dimensions:||7.00(w) x 9.90(h) x 1.00(d)|
About the Author
Frank J. Lovicu is a Senior Lecturer at the Save Sight Institute and in the Department of Anatomy and Histology, Institute for Biomedical Research, at the University of Sydney, Australia. He currently heads the Lens Research Laboratory in the Department of Anatomy & Histology, where he studies the role of growth factors in regulating normal and aberrant lens cell behavior.
Michael L. Robinson is an Assistant Professor in the Department of Pediatrics at The Ohio State University, USA. He also heads the Transgenic and Embryonic Stem Cell Core Facility at Columbus Children's Research Institute. Dr Robinson's research is focused on the role of FGF receptor signaling during lens fiber cell differentiation.
Table of Contents
Part I. Early Lens Development: 1. The lens: historical and comparative perspectives Michael L. Robinson and Frank J. Lovicu; 2. Lens induction and determination Marilyn Fisher and Robert M. Grainger; 3. Transcription factors in early lens development Guy Goudreau, Nicole Andrejewski and Peter Gruss; Part II. The Lens: 4. The structure of the vertebrate lens Jer R. Kuszak and M. Joseph Costello; 5. Lens crystallins Melinda K. Duncan, Ales Cvekl, Marc Kantorow and Joram Piatigorsky; 6. Lens cell membranes Joerg Kistler, Reiner Eckert and Paul Donaldson; 7. Lens cell cytoskeleton Roy Quinlan and Alan Prescott; Part III. Lens Development and Growth: 8. Lens cell proliferation: the cell cycle Anne E. Griep and Pumin Zhang; 9. Lens fiber differentiation Steven Bassnett and David Beebe; 10. Role of matrix and cell adhesion molecules in lens differentiation A. Sue Menko and Janice L. Walker; 11. Growth factors in lens development Richard A. Lang and John W. McAvoy; 12. Lens regeneration Katia Del Rio-Tsonis and Goro Eguchi.