Developmental and Reproductive Toxicology

Developmental and Reproductive Toxicology

by Ali S. Faqi (Editor)

Hardcover(1st ed. 2017)

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Developmental and Reproductive Toxicology by Ali S. Faqi

This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab.

Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers working in this vital field of study.

Product Details

ISBN-13: 9781493972067
Publisher: Springer New York
Publication date: 08/18/2017
Series: Methods in Pharmacology and Toxicology
Edition description: 1st ed. 2017
Pages: 314
Product dimensions: 7.01(w) x 10.00(h) x (d)

Table of Contents

1. Metabolism and Drug-Drug Interaction in Pregnant Mother/Placenta/Fetus

Ali S. Faqi and Karsten A. Holm

2. Critical Periods of Development in Teratology

Padmanahban Rengasamy

3. Nonclinical Safety Assessment of Developmental and Reproductive Toxicology: Considerations for Conducting Fertility, Embryo-Fetal Development, and Pre- and Postnatal Developmental Toxicology Studies

Kevin H. Denny and Ali S. Faqi

4. A Developmental and Reproductive Toxicology Program for Chemical Registration

Kamin J. Johnson, Bethany R. Hannas, Sue Marty, Carol L. Zablotny, Jessica LaRocca, Nicholas Ball, and Amanda

K. Andrus

5. The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility

Sellappan Selvaraju, Meritxell Jodar, and Stephen A. Krawetz

6. Effects of Chemicals on Mammary Gland Development

Adam Filgo and Ali S. Faqi

7. Alternative Methods Used to Assess Potential Embryo-Fetal Developmental Risk of Pharmaceuticals

Maia L. Green, Joshua Gamse, and Kimberly C. Brannen

8. Using the Alternative Model C. elegans in Reproductive and Developmental Toxicology Studies

Daniel Ferreira, Yichang Chen, and Patrick Allard

9. High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays

Quanwen Li, Yu Yang, Erica Louden, Elizabeth E. Puscheck, and Daniel A. Rappolee

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