This volume contains the proceedings of the 10th Japan-Korea Symposium on Diabetes Mellitus, held every two years, this time in Japan during October 1999. The aim of this symposium was to present and discuss recent progress, and to achieve further advances in the field of diabetes mellitus. The symposium consisted of five lectures on results of UKPDS, epidemiology and complications of diabetes mellitus, molecular mechanisms of insulin action and insulin secretion, two symposia about pathogenesis and treatment of diabetes mellitus and seventeen free communication sessions covering all the fields of diabetes mellitus. This volume reflects the most up-to-date knowledge in this important area.
Table of ContentsLectures.
Clinical implications from the United Kingdom Prospective Diabetes Study (D.R. Hadden). Characteristics of Korean type 2 diabetes mellitus and impaired glucose tolerance patients (H.Y. Son). Molecular mechanism of insulin signal transduction (M. Kasuga et al.). Molecular mechanism of insulin secretion (K. Miyawaki et al.).
Genetic susceptibility factors of type 1 diabetes and their functional evaluation (Y. Park). Molecular analysis of the cause of type 1 diabetes (T. Hanafusa). Molecular analysis of the defects in insulin secretion in Japanese NIDDM (H. Furuta, T. Sanke, K. Nanjo). Therapeutic effects of glimepride on type 2 diabetes in Korea (L. Hyunchul). Islet transplantation (K.-W. Kim, M.-K. Lee, Y.-H. Bae). Impact of PKC beta inhibitor on diabetic complications (H. Nawata et al.).
Free Communications. Epidemiology.
Diabetes care asia: final country report on outcome data collection and analysis - Korea (Y.S. Kim et al.). Comparison of clinical characteristics of impaired fasting glucose with impaired glucose tolerance in a korean population (S. W. Kim et al.). New ADA diabetes criteria in Korean population: fasting blood glucose is not enough for diagnosis of diabetes in Korean subjects especially in elderly (Y.H. Choi et al.).
Etiology of IDDM.
A shift of nonketotic hyperosmolar coma to ketone production in a 4-month-old infant (D.K. Jin, J.S. Kim, S.M. Song). Role of Fas/FasL interaction in the NOD autoimmune diabetes (M. Nakayama et al.). Typing of microsatellite markers within HLA region using the primer extension preamplification (PEP) method (Y. Kawabata et al.). Associations of distal chromosome 2q with type 1 diabetes in Japanese subjects (M. Nishino et al.). Follow up study of endogenous insulin secretion in GAD-Ab(+) NIDDM. Report of West Japan (Kyushu, Yamaguchi, Osaka) study for GAD-Ab(+) diabetes (Y. Sera et al.).
Etiology of NIDDM.
Effect of environmental factors on phenotypic characteristics of spontaneously diabetic NSY mice (K. Nojima et al.). Lack of association between hepatocyte nuclear factor genes and common forms of type 2 diabetes in the Japanese population (N. Babaya et al.). Impaired insulin secretion in addition to insulin resistance contributes to the development of overt diabetes in Werner's syndrome (K. Yamada et al.). Insulin secretory impairment wasn't recovered even after tight blood glucose control in non-obese type 2 diabetic patients in Korea (S.A. Chang et al.). Decreased mitochondrial DNA content is a possible link between fetal undernutrition and insulin resistance (S.K. Kim et al.).
Effects of thiazolidinedione on insulin secretion (T. Kakizawa et al.). PIP2 and ATP synergistically prevent disarrangement of ATP-sensitive K+ channels induced by elevation of cytosolic Ca2+ in rat pancreatic â-cells (N. Koriyamaet al.). Glutathione regulates the transcriptional activation of insulin gene expression in pancreatic â-cells (M. Ozakiet al.).
Effectiveness of insulin-like growth factor-I in a patient with type B insulin resistance (N. Fujita et al.). Phosphorylation of the insulin receptor by immunoglobulin G in a patient with type B insulin resistance (H. Yamasaki et al.). A mutation study of insulin receptor gene in a patient with leprechaunism (J.S. Kim, D.K. Jin). Dynamic control of the hepatic parasympathetic nerve dependent component of insulin action (S. Takayama, D.J. Legare, W.W. Laut). The negative regulation of insulin signaling by PTEN/MMAC1 in 3T3-L1 adipocytes (N. Nakashima et al.). Peroxisome proliferator-activated receptor-ã (PPAR-ã) expression and vascular smooth muscle cell proliferation (M.-K Lee et al.).
Metabolism/Other Hormones and Peptide.
Comparison of plasma lipids in type 2 diabetics between Korea and Japan (S. Komori et al.). Clinical investigation on post-prandial hyperlipidemia; increase of remnant-like particles' cholesterol level after lunch (H. Takeda, T. Uemura, R. Yoshimura). Responses of plasma triglyceride to fat load in type 2 diabetic patients with normal triglyceride level (M. Okada et al.). The effect of vitamin E supplementation on oxidative stress in Korean type 2 diabetic patients with continuous subcutaneous insulin infusion (CSII) therapy (S. Park et al.). Role of remnant-like particles (RLPs) from diabetic patients on cholesteryl ester synthesis (M. Saito et al.). Overexpression of human insulinoma PFK2/F2,6DPase in rat primary cultured hepatocytes: key role of F2,6DP in glucagon effects on hepatic glucose metabolism (T. Ohji et al.). Secretion of anterior pituitary hormones in patients with non-insulin dependent diabetes mellitus (I.M. Yang et al.).
Islet cell/Beta cell.
In vitro expansion and differentiation of islet precursor cells from cultured neonatal porcine pancreatic tissue (K.H. Yoon et al.). Intermediate filament expression in pancreatic ductal cells after 90% pancreatectomy in rats (S.H. Ko et al.). Involvement of tumor necrosis factor-á signaling pathway in pancreatic beta-cells apoptosis (N. Ishizuka et al.). Differentiation and expansion of beta-cell mass in porcine neonatal pancreatic cell clusters transplanted into diabetic nude mice (K.H. Yoon et al.).
Clinical feature of peripheral polyneuropathy in diabetic outpatients (K. Hirashima et al.). The ability of routine foot care in elderly diabetic patients (D.S. Yoo et al.). Autonomic nerve dysfunction in diabetic patients (K. Ogawa et al.). A case of post-treatment diabetic autonomic neuropathy (S. Teno et al.). Clinical application of electrogastrography in type 2 diabetic gastroparesis (S.B. Hong et al.). Prostaglandin E1 ameliorates impaired nerve regeneration in diabetic rats through increasing cAMP and inhibiting c-jun N-terminal kinase pathway (S. Kogawa et al.).
Peroxisome proliferator-activated receptor ã (PPARã) expresses in rat mesangial cells (T. Asano et al.). Mitochonfrial genotype Mt5178C is associated with diabetic nephropathy in Japanese type-1 diabetic patients (J. Miura et al.). High glucose induced extracellular matrix gene transcription is not mediated by expression of TGF-â1 in cultured NRK cells (M. Fujiki et al.). Changes of glomerular basement membrane components in vacor-induced diabetic nephropathy (T.H. Lee, Y.D. Seon, M.C. Lee). Effect of 5-hydroxytryptamine2A receptor antagonist on the development of diabetic nephropathy in early stage (S. Kobori et al.). Urine levels of vascular endothelial growth factor (VEGF) in type 2 diabetic patients (N.H. Kim et al.). Increased peripheral vascular resistance as a risk factor for developing early diabetic nephropathy in Japanese normo-tensive NIDDM Patients (M. Nomura et al.). Effect of intensive protein restriction on diabetic nephropathy; multicenter randomized controlled study in Fukuoka (K. Nunoi et al.).
Normalization of glucose entry with phlorizin and captopril attenuates high glucose-induced morphological and functional changes of bovine retinal pericytes (M. Wakisaka et al.).
Analysis of factors related intima media thickness of carotid artery in subjects with type 2 diabetes (C.W. Ahn et al.). Effect of Prostaglandin E1 on arteriosclerosis obliterans in diabetic patients (H. Sano et al.). Highly calcified coronary artery detected by electron beam computed tomography predicts an ischemic heart disease in diabetic patients (M. Hosoi et al.). G192R variant of paraoxonase 1 gene is is associated with ischemic heart disease in Japanes patietns with type 2 diabetes mellitus (M. Odawara et al.). Relation between atherosclerosis and polymorphism of the NADH/NADPH oxidase p22 phox gene in type 2 diabetes (R. Hayaishi-Yoshioka et al.). Plasma homocysteine is related to the macrovascular complications in patients with type 2 diabetes (S.W. Park et al.). High glucose induces injury of endothelial cells by activation of neutrophils: implications for the early vascular damage in diabetes (I.J. Kim et al.). Activation of diacylglycerol and protein kinase C by oxidants and advanced glycation end-products in vascular cells (T. Yamauchi et al.). Silent myocardial ischemia in patients with multiple coronary risk factors including abnormal glucose tolerance (Y. Hashiguchi et al.).
Comparison of 8-year prospective follow-up in elderly and non-elderly diabetics (Y. Goriya, S. Takizawa). Questionnaire study of sexual dysfunction in urban diabetic men (H. Ueda, H. Taniguchi, K. Yokono).
High incidence of congenital malformations in infants of diabetic mothers first diagnosed during pregnancy (M. Sanaka et al.). Role of apoptosis and the expression of bax and bcl-2 on diabetic embryopathy (F. Sun et al.).
Characteristics of subjects with type 2 diabetes in the aspect of insulin resistance in Korea (C.W. Ahn et al.). An interview-based assessment of eating behaviors in diabetic and control subjects (M. Shintani et al.). Insulin resistance and erythrocyte sorbitol levels in obese subjects with impaired glucose tolerance (IGT) (H. Hosojima). Association of polymorphisms in the â2-adrenergic receptor gene with obesity and obesity-related metabolic disorders: comparison with â3-adrenergic receptor gene polymorphism (K. Yamada et al.). Molecular scanning for mutations in the melanocortin-4 receptor gene in obese/diabeyic Japanese (Y. Ohshiroet al.). The effect of fluoxetine on insulin resistance in 90% pancreatectomized rats (S.B. Choi et al.). Effect of oral nicotin administration on insulin secretion and insulin resistance in Zucker fatty rats (R.H. Liu, T. Kurose, S. Matsukura). Changes in the amount and function of gi proteins in the liver cells of streptozotocin-induced diabetic rats (B.Y Cha et al.). Obese IRS-1 hetero knockout (IRS-1(+/-)) mice are insulin resistant compared to obese wild type (IRS-1(+/+)) mice (A. Shirakami et al.). New constructed UCPI vector for adipocyte ablation with ganciclovir (W.H. Choi).
Insulin Therapy/Delivery System.
Usefulness of saliva glucose as a marker of blood glucose (M. Okubo et al.). Non-invasive blood glucose measurement by Fourier transform infrared spectroscopic analysis through the mucous membrane of the lip using chalcogenide optical fiber system (K. Nishida et al.). Serum CPR for clinical decision on selecting a therapeutic method for type 2 diabetic patients (T. Motomiya, S. Kitamura, K. Matsuoka). Effects of a practice guideline on insulin therapy in type 2 diabetic patients: before and after introducing Staged Diabetes Management (Y. Watanabe et al.). Study of new, visual plasma glucose date management system for self-management of plasma glucose (M. Kawaguchi et al.).
Oral Antidiabetic Agents.
Effect of troglitazone, an insulin sensitizer, on liver function in patients with type 2 diabetes mellitus (M. Onoet al.). Effect of long-term administration of troglitazone and body fat distribution in type 2 diabetic patients (S. Akazawa et al.).
Diet and Exercise.
Energy expenditure and treatment of diabetes mellitus (M. Itoi et al.). Effect of relatively high carbohydrate and low fat japanese diet in the nutritional management of gestational diabetes (A. Yamashita et al.). The effect of exercise on the mitochondrial DNA copy number in peripheral blood in healthy women (S. Limet al.).
Index of authors.