Diverse Effects of Hypoxia on Tumor Progression

Diverse Effects of Hypoxia on Tumor Progression

by M. Celeste Simon (Editor)


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Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance. Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration

Product Details

ISBN-13: 9783642264849
Publisher: Springer Berlin Heidelberg
Publication date: 11/05/2012
Series: Current Topics in Microbiology and Immunology , #345
Edition description: 2010
Pages: 146
Product dimensions: 6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

Preface.- The HIF-2alpha-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation and vascularization.- Hypoxia and hypoxia inducible factors in cancer stem cell maintenance.- Role of carcinoma-associated fibroblasts and hypoxia in tumor progression.- the role of hypoxia regulated microRNAs in cancer.- Hypoxia-inducible factors as essential regulators of inflammation.- Hypoxia and metastasis in breast cancer. Subject Index

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