DNA Damage and Repair in Human Tissues

DNA Damage and Repair in Human Tissues

Paperback(Softcover reprint of the original 1st ed. 1990)

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Product Details

ISBN-13: 9781461279037
Publisher: Springer US
Publication date: 10/12/2011
Series: Basic Life Sciences , #53
Edition description: Softcover reprint of the original 1st ed. 1990
Pages: 474
Product dimensions: 6.69(w) x 9.61(h) x 0.04(d)

Table of Contents

DNA Lesion Measurement in Human Tissues.- Measurement of DNA Adducts by Immunoassays.- Detection of Human DNA Adducts by 32P-Postlabeling.- Immunologic Methods for the Detection of Carcinogen Adducts in Humans.- Lesion Measurement in Non-Radioactive DNA by Quantitative Gel Electrophoresis.- Fluorescence Detection of Lesions in DNA.- Damage and Repair in Skin.- Solar Radiation Induced Skin Cancer and DNA Photoproducts in Humans.- Defective DNA Repair in Humans: Clinical and Molecular Studies of Xeroderma Pigmentosum.- 5-MOP Induced Protection Against Epidermal DNA Damage by Ultraviolet Radiation in Human Skin.- Variability in DNA Repair in Human Skin.- Effects of Chemicals on Photobiologic Reactions of Skin.- Repair of 8-MOP Photoadducts in Human Lymphocytes.- Human Skin: Biochemistry and Molecular Biology.- DNA Damage and Repair in Human Skin: Pathways and Questions.- Unscheduled DNA Synthesis in Human Skin.- DNA Repair in Mammalian Tissues and Cells.- Damage Specific Mammalian Endonucleases.- Model Systems for Human Skin.- Characteristics of DNA Excision Repair in Nondividing Xeroderma Pigmentosum Cells, Complementation Group C.- Prospects for Epithelial Gene Therapy.- The Significance of DNA Damage and Repair Mechanisms in Health Risk Assessment.- DNA Damage and Repair in Human Blood Cells.- Measurements of Genomic and Gene-Specific DNA Repair of Alkylation Damage in Cultured Human T-Lymphocytes.- Peripheral Blood Leukocytes as a Surrogate Marker for Cisplatin Drug Resistance: Studies of Adduct Levels and the Repair Gene ERCCl.- Factors Which Affect DNA Repair in Human Lymphocytes.- Methyl Transferase Activity in Secondary Leukemia.- The Single Cell Gel Assay: A Sensitive Technique for Evaluating Intracellular Differences in DNA Damage and Repair.- Detection and Analysis of Human Mutations.- Cytogenetic Investigations of DNA Damage in Aging: A Twin Study.- Studies of DNA Alterations in In Vivo Somatic Cell Mutations in Humans.- Mechanisms of Induction of Specific Chromosomal Alterations.- Unfolding Perspectives on the Genetic Effects of Human Exposures to Radiation.- Effects of Caloric Restriction on the Maintenance of Genetic Fidelity.- Internal Organs.- Oncogenes and Tumor Suppressor Genes Involved in Human Lung Carcinogenesis.- Activation of Carcinogens by Human Liver Cytochromes P-450.- Repair of 06-Methylguanine Damage in Normal Human Tissues.- Repair of 04-Alkylthymine Damage in Human Cells.- Alkylation Repair in Human Tissues.- Participants.

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