Doping, Performance-Enhancing Drugs, and Hormones in Sport: Mechanisms of Action and Methods of Detection examines the biochemistry and bioanalytical aspects of performance-enhancing drugs (PEDs) and other questionable procedures used by athletes to enhance performance. The book informs the specialist of emerging knowledge and techniques and allows the non-specialist to grasp the underlying science and current practice of the discipline.
With clear and compelling language appropriate for a broad spectrum of readers, this book provides background on prevalence, types of agents, their actual or supposed benefits, and their negative effects on health. The technical aspects of detection are discussed, followed by a discussion of why detection is a problematic and still-evolving science. To facilitate comprehension, each chapter is organized in a uniform way with six sections: (1) standard medical uses, (2) why the drugs are used by athletes, (3) biological mechanism of action, (4) what research says about efficacy in improving performance, (5) major health side effects from use and abuse in sport, and 6) concluding key points.
- Presents the scientific concepts of how performance enhancers work, how they are used, and how they are detected and masked from detection
- Features language that is neither simplistic to scientists nor too sophisticated for a large, diverse global audience
- Provides a short “close-up” in each chapter to illustrate key topics that engage, entertain, and create a novel synthesis of thought
About the Author
Dr. Anthony C. Hackney is a Professor of Exercise Physiology and Nutrition at the University of North Carolina, Chapel Hill. His research group studies how stress affects the hormonal responses of the endocrine system. In particular, his focus is on the dysfunctions and dysregulations that develop from stress exposures which can ultimately compromise physiological responses and adaptations. Dr. Hackney is an editor and author of the successful books Endocrinology of Physical Activity and Sport and Sex Hormones, Exercise and Women, as well as author of the Elsevier book Exercise, Sport, and Bioanalytical Chemistry: Principles and Practice. He has published over 200 peer-reviewed research papers and book chapters, given over 150 national and international scientific conference presentations, and has had current and previous research projects funded by the National Institutes of Health, Department of Defense, USAID, and the National Academy of Sciences. He is an Editorial Board member for five exercise science, sports medicine, and physiology journals; has done visiting professorships in Uruguay, Kosovo, Norway, New Zealand, Germany, and Estonia; and is on the Board of Directors of the Center for the Study of Retired Athletes, UNC-CH. A recipient of three Fulbright Scholar awards, he was named Fellow, American Academy of Kinesiology (2010), Montoye Research Scholar, the American College of Sports Medicine (2015), Fellow, Huffines Institute for Sports Medicine (2015), and Kean-Pogue Senior Research Scholar, University of North Carolina (2016), among other honors and awards.
Table of Contents
1. Overview: Doping in Sport
2. Anabolic Androgenic Steroids
5. Peptide-Protein Hormones
6. Beta-2 Agonists
7. Hormone and Metabolic Modulators
9. Beta Blockers
10. Athlete Testing, Analytical Procedures, and Adverse Analytical Findings
11. The Future of Performance Enhancement in Sport