Table of Contents
PREFACE viii CONTRIBUTORS x
PART I HISTORY, APPLICATIONS, AND HEALTHCARE
1 Overview of the History and Applications of Dried Blood Samples 3 W. Harry Hannon and Bradford L. Therrell, Jr.
2 Dried Blood Spot Cards 16 Brad Davin and W. Harry Hannon
3 Dried Blood Spot Sample Collection, Storage, and Transportation 21 Joanne Mei
4 Dried Blood Spot Specimens for Polymerase Chain Reaction in Molecular Diagnostics and Public Health Surveillance 32 Chunfu Yang
5 Application of Enzyme Immunoassay Methods Using Dried Blood Spot Specimens 40 Mireille B. Kalou
6 Applications of Dried Blood Spots in Newborn and Metabolic Screening 53 Donald H. Chace, Alan R. Spitzer, and Víctor R. De Jesús
7 Dried Blood Spots for Use in HIV-Related Epidemiological Studies in Resource-Limited Settings 76 Sridhar V. Basavaraju and John P. Pitman
8 Use of Dried Blood Spot Samples in HCV-, HBV-, and Influenza-Related Epidemiological Studies 95 Harleen Gakhar and Mark Holodniy
9 Applications of Dried Blood Spots in General Human Health Studies 114 Eleanor Brindle, Kathleen A. O’Connor, and Dean A. Garrett
10 Applications of Dried Blood Spots in Environmental Population Studies 130 Antonia M. Calafat and Kayoko Kato
11 The Use of Dried Blood Spots and Stains in Forensic Science 140 Donald H. Chace and Nicholas T. Lappas
PART II PHARMACEUTICAL APPLICATIONS
12 Pharmaceutical Perspectives of Use of Dried Blood Spots 153 Christopher Evans and Neil Spooner
13 Punching and Extraction Techniques for Dried Blood Spot Sample Analysis 160 Philip Wong and Christopher A. James
14 Considerations in Development and Validation of LC-MS/MS Method for Quantitative Analysis of Small Molecules in Dried Blood Spot Samples 168 Wenkui Li
15 Challenges and Experiences with Dried Blood Spot Technology for Method Development and Validation 179 Chester L. Bowen and Christopher A. Evans
16 Clinical Implications of Dried Blood Spot Assays for Biotherapeutics 188 Matthew E. Szapacs and Jonathan R. Kehler
17 Potential Role for Dried Blood Spot Sampling and Bioanalysis in Preclinical Studies 195 Qin C. Ji and Laura Patrone
18 Clinical and Bioanalytical Evaluation of Dried Blood Spot Sampling for Genotyping and Phenotyping of Cytochrome p450 Enzymes in Healthy Volunteers 202 Theo de Boer, Izaak den Daas, Jaap Wieling, Johan Wemer, and LingSing Chen
19 Application of Dried Blood Spot Sampling in Clinical Pharmacology Trials and Therapeutic Drug Monitoring 216 Kenneth Kulmatycki, Wenkui Li, Xiaoying (Lucy) Xu, and Venkateswar Jarugula
20 Automation in Dried Blood Spot Sample Collection, Processing, and Analysis for Quantitative Bioanalysis in Pharmaceutical Industry 229 Leimin Fan, Katty Wan, Olga Kavetskaia, and Huaiqin Wu
21 Beyond Dried Blood Spots—Application of Dried Matrix Spots 235 Shane R. Needham
PART III NEW TECHNOLOGIES AND EMERGING APPLICATIONS
22 Direct Analysis of Dried Blood Spot Samples 245 Paul Abu-Rabie
23 Paper Spray Ionization for Direct Analysis of Dried Blood Spots 298 Jiangjiang Liu, Nicholas E. Manicke, R. Graham Cooks, and Zheng Ouyang
24 Direct Solvent Extraction and Analysis of Biomarkers in Dried Blood Spots Using a Flow-Through Autosampler 314 David S. Millington, Haoyue Zhang, M. Arthur Moseley, J. Will Thompson, and Peter Smith
25 Development of Biomarker Assays for Clinical Diagnostics Using a Digital Microfluidics Platform 325 David S. Millington, Ramakrishna Sista, Deeksha Bali, Allen E. Eckhardt, and Vamsee Pamula
26 Applications and Chemistry of Cellulose Papers for Dried Blood Spots 332 Jacquelynn Luckwell, Åke Danielsson, Barry Johnson, Sarah Clegg, Mark Green, and Alan Pierce
27 Derivatization Techniques in Dried Blood Spot Analysis 344 Ann-Sofie M.E. Ingels, Nele Sadones, Pieter M.M. De Kesel, Willy E. Lambert, and Christophe P. Stove
INDEX 355