Drug Therapy 1999: A Critical Review of Therapeutics

Drug Therapy 1999: A Critical Review of Therapeutics

Hardcover

$59.95

Product Details

ISBN-13: 9780071349901
Publisher: McGraw-Hill Professional Publishing
Publication date: 03/28/1999
Pages: 461
Product dimensions: 6.28(w) x 9.34(h) x 1.64(d)

Table of Contents

Preface xxxi
New Drugs
Cardiovascular Disease
Clopidogrel (Plavix): A Rich Man's Aspirin
3(1)
Glycoprotein IIb/IIIa Receptor Blockers: Superaspirins for Acute Coronary Syndromes
4(2)
Lepirudin (Refludan) for Heparin-Induced Thrombocytopenia
6(1)
Angiotensin II Receptor Antagonists for Hypertension
6(1)
Fenoldopam (Corloplam) for Severe Hypertension
7(1)
Fenofibrate (Tricor) for Elevated Triglyceride Levels
8(1)
Cilostazol (Pletal): A New Drug for Intermittent Claudication
9(2)
Diabetes
Repaglinide (Prandin) for Type 2 Diabetes
11(1)
Recombinant Glucagon for Hypoglycemia
12(1)
Infectious Disease
Ribavirin Increases Effectiveness of Interferon in Hepatitis C
13(2)
Anti-HIV Drug for Chronic Hepatitis B
15(1)
Trovafloxacin (Trovan): A New Fluoroquinolone for a Wide Variety of Infections
16(1)
Synercid: A Drug Combination for Resistant Organisms
16(1)
Rifapentine (Priftin): New Treatment for Tuberculosis
17(1)
Sustiva: Another NNRTI for the Treatment of HIV Infection
18(1)
Abacavir (Ziagen): An NRTI Alternative to HIV Protease Inhibitors
19(2)
Inflammatory Disease
Hyaluronic Acid Derivatives for Osteoarthritis
21(1)
Leflunomide (Arava) for Rheumatoid Arthritis
21(2)
Mental Health
Citalopram (Celexa): A New SSRI for the Treatment of Depression
23(2)
Neurological Disease
Tolcapone (Tasmar): First COMT Inhibitor for Parkinson's Disease
25(1)
New Triptans for Migraine
26(2)
Tiagabine (Gabitril) for Partial Seizures
28(2)
Obesity
Sibutramine (Meridia) for Weight Reduction
30(2)
Oncology
Implanted Wafers for Treatment of Brain Tumors
32(1)
Irinotecan (Camptosar) for Colorectal Cancer
32(1)
Valrubicin (Valstar): A New Drug for Bladder Cancer
33(1)
Alitretinoin Gel (Panretin) for Kaposi's Sarcoma
33(1)
Cytarabine Liposome Injection (DepoCyt) for Lymphomatous Meningitis
33(2)
Pain Management
Fentanyl: An Old Drug in a New Form for Serious Pain
35(1)
FDA Panel Recommends Approval for COX-2 Inhibitor Celecoxib (Celebrex)
35(2)
Respiratory Disease
Tobramycin for Inhalation as Treatment for Cystic Fibrosis
37(1)
Montelukast (Singulair) for Adults and Children with Asthma
37(2)
Women's Health
Raloxifene (Evista): A Designer Estrogen for the Prevention of Osteoporosis
39(2)
Estrogen/Progestin Transdermal Patch
41(1)
Toremifene and Letrozole: Anti-Estrogen Therapy for Breast Cancer
42(1)
Capecitabine (Xeloda): Oral Treatment for Metastatic Breast Cancer
42(2)
Men's Health
Viagra for Male Erectile Dysfunction
44(8)
Propecia for the Prevention and Restoration of Hair Loss in Men
52(2)
Other Indications
Hydroxyurea in Sickle Cell Anemia
54(1)
New Drugs for Bladder Control
55(1)
Thalidomide (Thalomid) for Leprosy-Related Condition
56(1)
Doxycycline for Periodontal Disease
57(2)
Topical Brinzolamide for Glaucoma
59(1)
Risedronate (Actonell) for Paget's Disease
59(1)
Late Breaking Reports
Infectious Disease
59(1)
Oncology
60(1)
Pain Management
60(1)
Respiratory Disease
60(1)
Women's Health
61(1)
Other Indications
61(4)
Drug Evaluation: Controlled Clinical Studies
Cardiovascular Disease
Aspirin and Warfarin Prevent First Heart Attack
65(2)
Long-Term Oral Anticoagulant Therapy for Acute Coronary Syndromes
67(1)
Computer-Guided Dosing of Warfarin Outperforms Traditional Dosing
68(1)
Ticlopidine (Ticlid) Effective for Angioplasty but Adverse Effects Limit Use
68(1)
Abciximab (ReoPro) Shines in Angioplasty Trial
69(2)
Hirudin and Enoxaparin Show Benefit in Unstable Angina
71(1)
Addition of Enoxaparin Prevents Venous Thromboembolism after Surgery
72(1)
Limited Role for Drugs in Cardiac Arrest
73(1)
Lower Limit of LDL-Cholesterol Reduction Unresolved
73(2)
Simvastatin versus Atorvastatin
75(1)
Primary Prevention of Acute Coronary Events with a Statin
76(1)
Pravastatin Prevents Morbidity and Mortality in All Patients with Coronary Heart Disease
76(2)
Atorvastatin (Lipitor) May Reduce Need for Coronary Revascularization
78(1)
ACE Inhibitors for Heart Failure: Dosing Issues
79(1)
Spironolactone (Aldactone) Benefits patients with Heart Failure
80(1)
Bisoprolol: A β-Blocker for Heart Failure
80(1)
New Studies May Change Treatment Guidelines for Hypertension
81(2)
Selecting the Right Antihypertensive Agent
83(2)
Diabetes
Troglitazone in Patients with Type 2 Diabetes Mellitus
85(1)
Multiple Benefits of ACE Inhibitors in Patients with Diabetes
86(2)
Early, Intensive Insulin Therapy Preserves Islet Function in Type 1 Diabetics
88(1)
Intensive Glucose Control for Type 2 Diabetes
88(3)
Tight Control of Blood Pressure for Type 2 Diabetes
91(1)
Improved Glucose Control with Glipizide Realizes Short-Term Benefits
91(2)
Gastrointestinal Disease
Prilosec versus Cytotec for NSAID-Induced GI Ulcers
93(1)
H Pylori Eradication of no Benefit for NSAID-Induced GI Ulcers
94(2)
Infectious Disease
Zinc Not Effective for Common Cold in Children
96(1)
Vitamin Supplements Decrease Adverse Pregnancy Outcomes in HIV-Infected Women
97(1)
Short-Term AZT Reduces Vertical Transmission of HIV
97(2)
Initial Therapy of HIV Infection: Conservative or Aggressive?
99(1)
Maintenance Therapy Fails to Maintain Suppression of HIV Load
100(1)
It's Not "Just the Virus Stupid"
101(2)
Lamivudine for Chronic Hepatitis B
103(1)
Acyclovir for Prevention of Ocular Herpes Infection
104(1)
Oral Famciclovir for Suppression of Recurrent Genital Herpes
105(2)
Inflammatory Disease
Budesonide and Mesalamine for Active Crohn's Disease
107(1)
Mental Health
Old Versus New Antidepressants for Patients with Heart Disease
108(1)
Paroxetine (Paxil) for the Treatment of Social Anxiety Disorder
109(1)
Long-Term Sertraline of Benefit for Chronic Depression
110(1)
Neurological Disease
Excedrin-Extra Strength to Treat Migraine Headache
111(1)
Riboflavin to Prevent Migraine Headache
112(1)
Best Treatment for Status Epilepticus
112(1)
New Dosage Forms to Treat Acute Repetitive Seizures
113(1)
Selegiline-Levodopa Combination Increases Mortality for Patients with Parkinson's Disease
114(1)
Dopamine Agonist---Pramipexole---Reduces Tremor in Parkinson's Disease
115(1)
Donepezil (Aricept) Improves Cognition and Function in Alzheimer Disease
115(1)
Drug Therapy for Multiple Sclerosis
116(2)
Obesity
Olestra and Gastrointestinal Symptoms
118(1)
Oncology
Tamoxifen Reduces the Incidence of Breast Cancer
119(5)
Aspirin and Colon Cancer
124(1)
Optimizing Chemotherapy for Childhood Acute Lymphoblastic Leukemia
125(1)
Palliative for Prostate Cancer Offers No Benefit
126(1)
Carboplatin Monotherapy as Effective as Combination Therapy in Ovarian Cancer
126(2)
Pain Management
Preemptive Analgesia Gives Mixed Results
128(1)
Respiratory Disease
Inhaled Corticosteroids and COPD
129(1)
Prolonged Corticosteroid Therapy Improves Acute Respiratory Distress Syndrome
130(1)
Montelukast (Singulair) and Salmeterol (Serevent) for Exercise-Induced Asthma
131(2)
Zafirlukast (Accolate) and Montelukast (Singulair) Show Promise in Asthma
133(1)
Nebulized Budesonide Compared with Intramuscular Dexamethasone for Croup
134(1)
Transplantation
Risk of Cancer in Kidney-Allograft Recipients
135(2)
Women's Health
Fosamax Prevents Bone Loss in Postmenopausal Women
137(1)
Estrogen/Bisphosphonate Combination for Osteoporosis
138(1)
Fluoride Decreases Vertebral Fracture Rates
139(1)
Parathyroid Hormone Prevents Bone Loss in Women Treated for Endometriosis
140(1)
Aspirin Does Not Prevent Preeclampsia
140(1)
Isosorbide Mononitrate for Cervical Ripening before Abortion
141(1)
Benefit of Emergency Contraception Available without a Prescription
142(1)
Better Tolerated and More Effective Emergency Contraception
143(1)
Bisphosphonate Reduces Risk of Breast Cancer Recurrence and Mortality
144(1)
Spermicide (Nonoxynol 9) Does Not Reduce Transmission of STDs
144(1)
Calcium Supplements Ameliorate PMS and May Provide Other Benefits
145(3)
Men's Health
Proscar Effective for Men with Enlarged Prostate Glands
148(2)
Children's Health
Growth Hormone for Short Normal Girls
150(1)
Sertraline (Zoloft) in Children and Adolescents with OCD
150(2)
Health in the Elderly
Lowering Blood Pressure Prevents Dementia in the Elderly
152(2)
Other Indications
Therapy to Ameliorate Steroid-Induced Osteoporosis
154(1)
Subcutaneous Compared with Intravenous Erythropoietin in Hemodialysis
155(1)
Tacrolimus for Atopic Dermatitis
156(1)
Late Breaking Reports
Cardiovascular Disease
156(3)
Gastrointestinal Disease
159(1)
Pain Management
160(1)
Women's Health
160(1)
Other Indications
161(4)
Drug Evaluation: Other Studies and Reports
Cardiovascular Disease
Statins for the Prevention of Stroke
165(1)
High-Dose Simvastatin Lowers Cholesterol and Triglycerides
166(1)
Stopping Antihypertensive Medication May Pose Risks
166(1)
β-Blockers---Not First-Line Therapy for Hypertension in the Elderly
166(1)
Heparin Therapy for Treatment of Acute MI in the Elderly
167(1)
Long-Term Benefit of a Thrombolytic Agent and Aspirin after MI
167(1)
New Indication for Aprotinin in Bypass-Graft Surgery
168(1)
Bleeding Risk Index May Improve Safety of Warfarin
168(1)
Underuse of Warfarin in Patients with Atrial Fibrillation and Ischemic Stroke
169(1)
β-Blockers in Chronic Heart Failure
169(1)
Diabetes
Type 1 Diabetes, Weight Gain, and Coronary Artery Disease
170(1)
Caution Needed in Prescribing Acarbose (Precose)
170(2)
Gastrointestinal Disease
New Ten-Day Regimens for Eradicating H pylori and Peptic Ulcer
172(1)
Proton Pump Inhibitors for Bleeding Peptic Ulcer
172(1)
Infectious Disease
British Guidelines for Anti-retroviral Treatment of HIV Infection
173(1)
Anti-HIV Therapy Reduces Morbidity and Mortality
173(1)
Treating STDs May Reduce Sexual Transmission of HIV
174(1)
Eradicating HIV in the Central Nervous System
175(1)
Managing Protease Inhibitor-Related Lipid Abnormalities
175(1)
Hydroxyurea May Benefit Patients with HIV Infection
176(1)
Directly Observed Therapy for Tuberculosis
176(1)
Optimizing the Dose of Interferon for Hepatitis C
177(1)
Restriction of Cephalosporin Use Reduces Resistant Klebsiella Infection
177(1)
Influenza Vaccination Benefits Low-Risk Elderly
178(1)
Concerted Effort to Eliminate Trachoma
178(2)
Inflammatory Disease
Corticosteroids for the Treatment of Rheumatoid Arthritis
180(1)
Cytotoxic Agents and Cyclosporine for Autoimmune Disease
180(2)
Mental Health
More Benefits of Current Generation of Antipsychotic Drugs
182(1)
SSRI Antidepressants and Weight Gain
182(2)
Obesity
Obesity Guidelines Caution on Drug Use
184(1)
Oncology
Cyclosporine Improves Oral Therapy with Taxol
185(1)
Arsenic Induces Complete Remission for a Form of Leukemia
185(2)
Respiratory Disease
Competing Inhaled Corticosteroids Not Equipment
187(1)
Women's Health
Hormone Replacement Therapy Decreases Risk of Colorectal Cancer
188(1)
Tamoxifen: Secondary Prevention of Breast Cancer
189(1)
Chemotherapy for Early Breast Cancer Improves Survival
189(1)
Estrogen Therapy: Effects on Cognitive Function and Dementia
190(1)
Estrogen Replacement Therapy and Breast Cancer Evidence
190(1)
Understanding and Treating Premenstrual Syndrome
191(1)
Oral Contraceptives and the Risk of Hereditary Ovarian Cancer
192(1)
Does Acetaminophen Protect Against Ovarian Cancer?
193(1)
Progestin-Only Oral Contraceptives May Increase the Risk of Type 2 Diabetes
193(1)
Cancer Risk in Women Exposed to Diethylstilbestrol in Utero
194(1)
Hormone Replacement Therapy Reduces Risk of Hip Fracture
194(1)
Meeting Reports Hold Promise for the Treatment of Osteoporosis
195(1)
Estrogen Replacement Therapy and Type 2 Diabetes
195(1)
Birth Control Pill for Acne
196(1)
Teenage Girls Favor Depot Contraceptive
196(1)
Low-Dose OCs Do Not Increase the Risk of a Heart Attack
197(1)
Sex Differences in Viral Load and Progression to AIDS
197(1)
Erythromycin Poses Greater Risk of Arrhythmias for Women
198(1)
Men's Health
Treatment of Sexual Deviation in Men
199(1)
Aging Men Lose Testosterone
199(1)
Aging Men Also Lose Estrogen and Develop Osteoporosis
200(1)
Children's Health
Growth Hormone Therapy for Children
201(1)
Survey Reveals Alarming Overuse of Antibiotics in Children
201(1)
Antidepressants Pose Low Risk to Fetus
202(1)
Cesarean Delivery May Reduce Risk of Vertical Transmission of HIV
202(1)
Risk Factors for Perinatal Transmission of HIV in Women Receiving AZT
203(1)
Abbreviated AZT Regimens Reduce Risk of Perinatal HIV Transmission
203(1)
Attempted Abortion with Misoprostol Increases the Risk of Birth Defect
204(1)
Pamidronate for Osteogenesis Imperfecta
204(2)
Health in the Elderly
Vitamin D Deficiency in the Sick and Elderly
206(1)
No Advantage of SSRIs over TCAs in Risk of Falls and Hip Fracture
206(1)
Inhaled Steroids and Cataracts in the Elderly
207(1)
Other Studies and Reports
Nasal Corticosteroids or Nonsedating Antihistamines for Allergic Rhinitis
208(1)
Liver Disease Selectively Decreases Activity of Drug-Metabolizing Enzymes
208(1)
Secretin Improves Behavior in Children with Autism
209(1)
Adverse Drug Effects
Acetaminophen is a Risk Factor for Excessive Warfarin Anticoagulation
210(1)
Regular Use of Aspirin May Increase the Risk of Stroke
211(1)
Ticlopidine May Result in TTP after Stenting
211(1)
Grapefruit Juice, Statins, and Adverse Effects
212(1)
Drug for CMV Retinitis May Lead to Renal Failure
212(1)
Benzodiazepines and Other CNS Drugs Impair Driving Skills
212(1)
Over-the-Counter NSAIDs May Cause Liver Damage in Patients with Hepatitis C
213(1)
Side Effects of Alendronate (Fosamax)
213(1)
Safety of Long-Term Use of Nicotine Replacement Products Questioned
214(1)
Risk of Intracranial Bleed after TPA for Acute MI
214(2)
Pharmacoeconomics
Introduction
216(1)
Preventing AIDS-Related Opportunistic Infections: Economic Implications
216(1)
Cost-Effectiveness of STD Treatment to Prevent HIV Infection in Africa
217(1)
Cost-Effectiveness of Drugs to Treat Schizophrenia
217(1)
Cost-Effectiveness of Smoking-Cessation Services
218(1)
The Cost of Gastroesophageal Reflux Disease
219(1)
Cyclosporine (Neoral) Faces Competition
220(1)
America's Soaring Drug Costs
220(3)
FTC Challenges Major Generic Drug Manufacturer's Prices
223(1)
Late Breaking Reports
Cardiovascular Disease
223(2)
Infectious Disease
225(1)
Other Studies and Reports
225(1)
Adverse Drug Effects
225(1)
Pharmacoeconomics
226(5)
In the Pipeline
Cardiovascular Disease
Treatment of Ischemic Stroke
231(1)
Endothelin Antagonists for the Treatment of Cardiovascular Disease
232(1)
Will Oral Glycoprotein IIb/IIIa Inhibitors Replace Aspirin?
233(1)
Novel Mechanism to Lower Cholesterol
234(2)
Gastrointestinal Disease
Isomer of Cisapride (Propulsid) Could Be Safer and Expand Indications
236(1)
Single Isomer Version of Omeprazole Better than Omeprazole
236(1)
Infectious Disease
New Pharmaceuticals May Mean Safer Sex for Women
237(1)
New Combination of Antiviral Drugs May Simplify HIV Therapy
238(1)
New Protease Inhibitor Offers Less Frequent Dosing
239(1)
The Next Wave of Anti-HIV Agents
239(2)
Treatment of Kaposi's Sarcoma
241(1)
New Drugs for the Treatment of Colds and Flu
241(1)
Oxazolidinone Antimicrobials for Multidrug-Resistant Infections
242(2)
Mental Health
New Indications for SSRI Antidepressants
244(1)
New Antidepressants Will Challenge Market Leaders
244(2)
New Way to Treat Schizophrenia
246(2)
Neurological Disease
Anti-Cancer Drug Benefits Patients with Multiple Sclerosis
248(1)
Obesity
Orlistat (Xenical): Novel Drug for Weight Loss
249(2)
Strategies and Potential Targets for the Treatment of Obesity
251(1)
Oncology
Photodynamic Therapy for Cancer
252(1)
Pain Management
New Nonopioid Analgesic
253(1)
Enhancing the Effects of Morphine
253(1)
New NSAIDs: An Array of Benefits without Stomach Damage
253(4)
Respiratory Disease
Combination Therapy for Asthma
257(1)
Substance Abuse
Blocking Glutamate May Help Alcoholics and Drug Addicts
258(1)
Transplantation
New and Important Immunosuppressant on the Horizon
259(1)
Women's Health
Combined Hormone Replacement for Postmenopausal Women
260(1)
Other Indications
Modafinil for Sleep Disorders
261(1)
Therapeutic Potential of Botulinum Toxin
261(1)
New Strategies for Male Contraception
262(1)
Late Breaking Reports
Infectious Disease
262(1)
Mental Health
263(1)
Pain Management
263(1)
Substance Abuse
264(4)
Vaccines
Introduction
New Products
Intranasal Flu Vaccine for Children
268(1)
Rotavirus Vaccine Now a Reality
269(2)
Lyme Disease Vaccine: Ready for the Summer of 1999
271(2)
In the Pipeline
Melanoma Vaccine: Early Stages
273(1)
Multicomponent Malaria Vaccine Fails to Prevent Infection
274(1)
DNA Vaccines Show Promise
274(3)
FDA Authorizes Phase III Testing for HIV Vaccine
277(1)
Other Strategies to Develop a Vaccine for HIV Infection
278(1)
A Vaccine Against Pneumococcal Meningitis and Bacteremia
279(2)
Other Issues
Vaccine Liability and Safety
281(1)
Activists Challenge Safety of Hepatitis B Vaccination Effort
282(1)
CDC Recommends Major Tuberculosis Vaccine Effort
283(1)
Late Breaking Reports
New Products
283(1)
Other Issues
284(3)
Biotechnology
New Products
Platelet-Derived Growth Factor (PDGF) for Diabetic Foot Ulcers
287(1)
Herceptin, a Monoclonal Antibody for Breast Cancer
287(2)
Infliximab (Remicade) for Crohn's Disease
289(2)
Palivizumab (Synagis) Prevents RSV Disease in Children
291(1)
Monoclonal Antibodies to Prevent Transplant Rejection
291(1)
Vitravene: First Antisense Agent Clears FDA Panel
292(1)
Advisory Committee Supports Approval of Stem-Cell Growth Factor
293(1)
FDA Approves Enbrel for Rheumatoid Arthritis
294(3)
In the Pipeline
Telomeres, Telomerase, Aging, and Cancer
297(1)
Nerve Growth Factor for Corneal Ulcers and Diabetic Neuropathy
298(1)
Replication-Competent Viruses for Tumors
299(1)
P53-Based Strategies to Keep Cancer in Check
300(1)
Blocking Oncogenes
301(1)
Monoclonal Antibodies for the Treatment of Cancer
302(1)
Matrix Metalloproteinases (MMPs) for the Treatment of Cancer
303(1)
New Therapies to Prevent Diabetic Retinopathy
303(1)
A Role for Pro-Inflammatory Cytokines in Heart Failure?
304(1)
Administering the Products of Biotechnology
304(2)
Replenishing Blood Components
306(2)
Small Molecule Drugs Substituting for Large Ones
308(1)
Leptin: The Antiobesity Hormone
308(1)
Leptin Triggers Angiogenesis
309(1)
A New Target for Anti-HIV Therapy
310(1)
The Search for Effective Strategies against Septic Shock
311(1)
Monoclonal Antibody to CD4 in Chronic Severe Asthma
312(1)
Pharmacologic Manipulation of Gene Expression
313(2)
Therapeutic Strategies
Antisense
315(2)
Apoptosis
Restoring a Cell's Ability to Die
317(3)
Angiogenesis
Introduction
320(1)
Angiogenesis and Tumor Progression
320(1)
Therapeutic Inhibition of Angiogenesis in Neoplastic Disease
321(2)
Angiogenesis Inhibitors and the Media
323(2)
Therapeutic Augmentation of Angiogenesis
325(3)
Gene Therapy
Delivering Genes to Target Sites Still a Major Hurdle
328(2)
In Utero Gene Therapy
330(2)
Monoclonal Antibodies
Human Antibodies by Design
332(2)
Pharmacogenomics
Genetic Strategies to Individualize Drug Therapy
334(1)
Late Breaking Reports
New Products
335(1)
In the Pipeline
336(1)
Therapeutic Strategies
337(5)
Alternative Medicine
Introduction
Clinical Studies
Vitamin E Cuts Risk of Prostate Cancer
342(1)
Multivitamins, Folate, and Colon Cancer in Women
343(1)
Vitamins, Homocysteine Levels, and the Risk of Cardiovascular Disease
343(2)
Ginkgo for Dementia
345(1)
Garlic Has No Effect on Elevated Cholesterol Levels
346(1)
DHEA for Aging
347(1)
Selenium May Protect Against Prostate Cancer
347(2)
Supplementing Fatty Acids in Infant Formula Enhances Problem Solving
349(1)
Cancer Cure Sweeps Italy
349(3)
Regulatory Issues
Huperzine for Alzheimer's Disease: End Run Around FDA
352(1)
FDA Challenges Marketing of Herb to Lower Cholesterol
353(1)
Medicated Skin Preparations---Drugs or Cosmetics?
354(1)
Sleep-Aid Found to be Contaminated
354(1)
The Safety of Dietary Supplements
355(3)
Other Reports
St. John's Wort for Depression
358(1)
Kava: The Next Herbal Superstar
359(1)
Saw Palmetto for Enlarged Prostate
359(1)
Soy Foods for Perimenopausal Estrogen Deficiency
360(1)
Androstenedione and Athletic Performance
360(1)
Horse Chestnut Seed Extract for Varicose Veins
361(1)
Brand-Name Companies Want a Piece of the Dietary Supplement Market
361(1)
The "Made in Italy" Answer to the Problem of Impotence
362(1)
Update on Vitamin Supplements
362(1)
JAMA Devotes November to Alternative Medicine
363(1)
Late Breaking Reports
Clinical Trials
364(1)
Regulatory Issues
364(1)
Other Reports
365(4)
Regulatory Actions and Issues
Drug Recalls and Warnings
Drug Interactions Drive Calcium Channel Blocker from Market
369(2)
Long-Term Use of Bromfenac (Duract) Results in Serious Toxicity
371(2)
Isotretinoin May Promote Depression
373(1)
FDA Wants New Drug Interaction Warnings for Astemizole (Hismanal)
373(1)
Safety Concerns Limit the Use of Cisapride (Propulsid)
374(1)
FDA Seeks to Remove Cancer Warning on Estrogen/Progestin Products
375(1)
Prolonged QT Interval Worries Regulators
375(1)
Thrombotic Thrombocytopenic Purpura Warning on Ticlopidine (Ticlid) Label
376(1)
Pediatric Warning on Inhaled Corticosteroids
376(2)
Authorities Restrict Use of Cough/Cold Preparations
378(1)
FDA Cautions about Use of Albumin in Seriously Ill Patients
378(1)
FDA Halts Distribution of Drug Used to Sterilize Women
379(1)
Alcohol Warnings for OTC Analgesics
379(1)
Regulatory Issues
Promotion of Pharmaceutical Products
380(4)
FDA to Require Pediatric Data on Drug Products
384(1)
Drug Industry Proposes Guidelines on Pharmacoeconomic Analysis
385(1)
Generic Drug Industry Wants Rule Changes
386(3)
FDA Not Protecting the Public, Say Critics
389(1)
FDA Establishes Post-Marketing Office
389(1)
Citizen's Group Petitions FDA on Inaccurate Patient Information
390(1)
Administration Nominates New FDA Commissioner
390(2)
Late Breaking Reports
Regulatory Actions
392(1)
Regulatory Issues
392(5)
Biomedical Ethics
New Marketing Practices Threaten Privacy
397(1)
Pharmaceutical Companies and Academic Researchers
398(2)
Protecting Human Research Subjects
400(3)
AIDS Vaccine Trials in the Third World
403(1)
Placebo-Controlled Clinical Trials
404(1)
Treatment of Patients with Terminal Disease
405(1)
Drug Companies Find Novel Ways to Thwart Generic Competition
406(1)
Rationing Scarce Drugs
407(1)
Late Breaking Reports
Questionable Anti-Generic Strategy Could Affect Merger Plan
408(1)
Protecting Human Research Subjects: An Update
408(3)
Therapeutic Controversies and Dilemmas
Cardiovascular Disease
Hypertension: Dramatically Undertreated
411(1)
The Treatment of Hypertension: Is There a Role for Calcium Channel Blockers?
411(3)
Underprescribing of β-Blockers after a Heart Attack
414(2)
TPA for the Treatment of Stroke
416(4)
Infectious Disease
Prophylactic Acyclovir and the Risk of Developing Drug-Resistant Herpesvirus
420(1)
Treatment of Infection for Secondary Prevention of Cardiovascular Events
420(2)
Drug-Resistant Microbes
422(1)
Principles of Therapy of HIV Infection and Guidelines for Use of Antiretroviral Agents
423(2)
Understanding and Treating HIV Infection: A Survey
425(8)
Oncology
High-Dose Chemotherapy and Autologous Bone Marrow Transplantation for Breast Cancer
433(2)
Rationing Taxol in the UK
435(1)
Pain Management
Undertreatment of Pain Remains a Serious Problem
436(2)
Substance Abuse
Methadone Clinics Challenged in New York City
438(2)
Women's Health
Birth Control by Means of Emergency Contraception
440(1)
Low-Dose Estrogen Oral Contraceptives and the Risk of Heart Attack
441(1)
Safety of Third Generation Oral Contraceptives
442(2)
Mifepristone (RU-486) and Misoprostol to Terminate Unwanted Pregnancy
444(1)
Hormone Replacement Therapy and Secondary Prevention of Heart Disease
445(3)
Children's Health
Drugs in Pregnancy
448(1)
Mandatory HIV Testing of Pregnant Women
449(2)
Adverse Drug Effects
Safety of Troglitazone in Patients with Type 2 Diabetes
451(1)
Are Drug Reactions A Major Cause of Death?
452(2)
Litigation on Recalled Diet Drugs
454(3)
Other Issues
Optimizing Clinical Trials May Reduce Applicability
457(1)
Failure to Adhere to Prescribed Drug Regimen
458(2)
Late Breaking Reports
Substance Abuse
460(3)
Index 463

Preface

Drug therapy is now the cornerstone of medicine, vital to every medical subspecialty. Even transplant procedures, the pinnacle of surgery today, would not be possible without drugs to prevent graft rejection. Keeping up with new developments in drug therapy is increasingly daunting. Health care professionals - doctors, pharmacists, and nurses-seek information that is easily assimilated and applicable. Professional caregivers often turn to information provided by the Physicians Desk Reference (PDR), by drug companies and their sales representatives, and by ads in trade journals. While these sources are useful, information is usually decontextualized; all too often, professional are left with the challenge of piecing together several sound bites.

The general public is increasingly aware of health-related issues and demands more information on medical technology and treatment. The media meets much of this demand. It is indeed uncommon when an issue of The Wall Street Journal or The New York Times does not contain and article on a pharmaceutical product. Even local papers have a rep9orter doing double duty in science and health. The media, however, frequently presents isolated, uncritical information, often providing no more than an edited version of a press release.

As pharmaceutical products loom large in the overall scheme of health care, pharmaceutical companies are now a darling of Wall Street. Business-oriented dailies and periodical are diligent in reporting news of pharmaceutical developments, especially about novel products and potential blockbusters that await regulatory approval. The reports tell of successes and failures, but many times do not present the entire picture.

In light of the increasing importance of pharmaceutical products in our society, there is a need to have and ongoing chronicle of drug therapy-an annual review of important new products; or new ways to safely use marketed products; of new ways to use drugs for the elderly, young children, and women; of breakthroughs in biotechnology; of new regulations that affect the development and marketing of pharmaceuticals; of the impact of drug therapy on health care costs; of ethical issues that influence the conduct of clinical trials; of important matters in the marketing and promotion of pharmaceuticals; and of new information on vitamins, other dietary supplements, and herbal medications. There has been no compilation of such information, no chronicle of progress. Now there is one--Drug Therapy 1999
--Milo Gibaldi

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