| Melissa McCarthy | Lee Israel |
| Richard Grant | Jack Hock |
| Dolly Wells | Anna |
| Jane Curtin | Marjorie |
| Ben Falcone | Alan Schmidt |
| Gregory Korostishevsky | Andrei |
| Stephen Spinella | Paul |
| Christian Navarro | Kurt |
| Pun Bandhu | Agent Doyle |
| Erik LaRay Harvey | Agent Solanas |
| Brandon Scott Jones | Glen |
| Shae D'Lyn | Nell |
| Rosal Colon | Rachel |
| Anna Deavere Smith | Elaine |
| Marc Evan Jackson | Lloyd |
| Marcella Lowery | Guest at Party |
| Roberta Wallach | Tom Clancy Groupie |
| Tina Benko | Karen |
| Sandy Rosenberg | Yale Librarian |
| Kevin Carolan | Tom Clancy |
Technical Credits
| Marielle Heller | Director |
| Bob Balaban | Executive Producer |
| Arjun Bhasin | Costumes/Costume Designer |
| Anne Carey | Producer |
| Stephen H. Carter | Production Designer |
| Jennifer Euston | Casting |
| Shani Geva | Associate Producer |
| Nate Heller | Score Composer |
| Pamela Hirsch | Executive Producer |
| Nicole Holofcener | Screenwriter |
| Karen Kane | Asst. Director |
| T.K. Knowles | Associate Producer |
| Anne McCabe | Editor |
| Marci Mudd | Art Director |
| Amy Nauiokas | Producer |
| Jawal Nga | Executive Producer |
| John O'Grady | Associate Producer |
| Howard Paar | Musical Direction/Supervision |
| Chuck Ryant | Associate Producer |
| Brandon Trost | Cinematographer |
| Joseph White | Sound Mixer |
| Jeff Whitty | Screenwriter |
| David Yarnell | Producer |
