| Viggo Mortensen | Tony Lip |
| Mahershala Ali | Dr. Don Shirley |
| Linda Cardellini | Dolores |
| Don Stark | Jules Podell |
| Sebastian Maniscalco | Johnny Venere |
| Dimiter Marinov | Oleg |
| Mike Hatton | George |
| P.J. Byrne | Record Exec |
| Joe Cortese | Gio Loscudo |
| Maggie Nixon | Copa Coat Check Girl |
| Von Lewis | Bobby Rydell |
| Jon Sortland | Rydell Band Leader |
| Anthony Mangano | Copa Bouncer Danny |
| Quinn Duffy | Mikey Cerrone |
| Paul Sloan | Copa Maitre D'Carmine |
| Seth Hurwitz | Johnny Randazzo |
| Hudson Galloway | Nick Vallelonga |
| Gavin Foley | Frankie Vallelonga |
| Rodolfo Vallelonga | Grandpa Nicola Vallelonga |
| Louis Venere | Rudy Vallelonga |
| Frank Vallelonga | Rudy Vallelonga |
| Brian Hayes Currie | Maryland State Trooper |
| Ninja N. Devoe | Orange Bird Bartender |
| Montrel Miller | Birimingham Hotel Waiter |
| Jon Michael Davis | Birmingham Hotel Maitre D' |
| Brian Stepanek | Graham Kindell |
| Dane Rhodes | Police Chief |
| Billy Breed | Patrolman #2 |
| Jim Klock | Patrolman #1 |
| David Simpson | Lousiana Host |
| Leslie Castay | Well-Dressed Woman |
| Dennis W. Hall | Mags |
| Craig DiFrancia | Dominic |
| Brian Distance | Macon Cop #2 |
| Daniel Greene | Macon Cop #1 |
| Shane Partlow | Tailor |
| Lindsay Brice | Frances Selden |
| lll Kermit Burns | Pimento Cheese Waiter |
| Christina Simpkins | Margaret Anderson |
| Tom Virtue | Morgan Anderson |
| Ricky Muse | Barkeep |
| Harrison Stone | Redneck #3 |
| James Evermore | Redneck #2 |
| David Kallaway | Redneck #1 |
| Floyd Miles | Floyd |
| Sam Malone | Horseshoe Man #1 |
| Gralen Bryant Banks | Horseshoe Man #1 |
| Ted Huckabee | Indiana Stage Manager |
| Martin Bats Bradford | Pittsburgh Busboy |
| Ron Flagge | Pittsburgh Chauffeur |
| Geraldine Singer | Pittsburgh MC |
| Gertrud Sigle | Marie |
| Peter Gabb | Charlie the Pawn Guy |
| Mike Cerrone | Joe and Joe's Customer |
| David An | Bobby |
| Nick Vallelonga | Augie |
| Sharon Landry | Carnegie Hall Manager |
| Iqbal Theba | Amit |
| Randal Gonzalez | Gorman |
| Johnny Williams | Fat Paulie |
| Derrick Spears | Bronx Floor Repairman #2 |
| Kenneth Israel | Bronx Floor Repairman #1 |
| Suehyla El-Attar | Lynn Venere |
| Jenna Laurenzo | Fran Venere |
| Don DiPetta | Louie Venere |
Technical Credits
| Peter Farrelly | Director,Producer,Screenwriter |
| Ashley Kent Bolotte | Makeup |
| Kristopher Bowers | Score Composer |
| Amanda Bravender | Makeup |
| Alan Breton | Asst. Director |
| Jonny Bullard | Makeup |
| Jim Burke | Producer |
| Brian Hayes Currie | Producer,Screenwriter |
| Luca DelPuppo | Cinematographer |
| Nicole Enna | Makeup |
| Steven Farneth | Executive Producer |
| Tim Galvin | Production Designer |
| Betsy Heimann | Costumes/Costume Designer |
| Courtney Jarrell | Makeup |
| Natalie Christine Johnson | Makeup |
| Jonathan King | Executive Producer |
| Nicole Reed LeFevre | Set Decoration/Design |
| Courtney Lether | Makeup |
| Darryl Lucas | Makeup |
| Annabelle MacNeal | Makeup |
| Michael R. Merriman | Cinematographer |
| Rick Montgomery | Casting |
| Kwame Parker | Executive Producer |
| Michael J. Payne | Sound/Sound Designer |
| Stacey Perry | Makeup |
| Scott Plauche | Art Director |
| Sean Porter | Cinematographer |
| Alejandro Ramia | Asst. Director |
| Manish Raval | Musical Direction/Supervision |
| James B. Rogers | Asst. Director,Co-producer |
| Andrew Shepherd | Asst. Director |
| Jeff Skoll | Executive Producer |
| John Sloss | Executive Producer |
| Octavia Spencer | Executive Producer |
| Ashley Treadaway | Makeup |
| Nick Vallelonga | Producer,Screenwriter |
| Ted Virtue | Co-producer |
| Patrick J. Don Vito | Editor |
| Charles B. Wessler | Producer |
| Tom Wolfe | Musical Direction/Supervision |
