Hollywood and Vine is set in a drugstore located at the intersection of the title. James Ellison plays a successful screenwriter who likes to do his research first-hand. Assigned to write a film about Hollywood hopefuls, Ellison gets a job as a drugstore soda jerk. Wanda McKay plays Daisy, a small-town girl with dreams of stardom who hangs out at the soda counter in hopes of being discovered. Despite its tiny budget and brief running time, Hollywood and Vine is jam-packed with prominent movie character people, including Franklin Pangborn, Ralph Morgan, Leon Belasco, Robert Grieg, and sometimes "Bowery Boy" Billy Benedict.