Ten strangers are brought together during a weather emergency, only to discover a far greater danger awaits them in this suspense-drama. A sudden rainstorm in a remote desert town strands a disparate variety of people at a rundown motel. A convict sentenced to death, Malcolm Rivers (Pruitt Taylor Vince), is stuck in transit with his lawyer (Alfred Molina). Ginny and Lou (Clea DuVall and William Lee Scott) are a not-especially-happy pair of young marrieds on their honeymoon. Ed (John Cusack) is a bright and resourceful chauffeur working for actress Caroline Suzanne (Rebecca De Mornay). George York (John C. McGinley) is a concerned husband trying to find help for his wife (Leila Kenzle, who was struck by Caroline's limo. Paris (Amanda Peet) is a prostitute who wants to move on to a better life. And Rhodes (Ray Liotta) is a police detective who has in his custody Robert Maine (Jake Busey), a dangerous and deranged criminal. As the rain pours down and motel manager Larry (John Hawkes) tries to care for his customers, one by one the unexpected guests begin losing their lives at the hands of a murderer. As the body count mounts, the stranded travelers struggle to find out who the killer is; however, they also learn each of them has a secret, and that their arrival at the motel has not been a matter of mere chance.