| Bryan Cranston | Chief |
| Edward Norton | Rex |
| Bill Murray | Boss |
| Jeff Goldblum | Duke |
| Bob Balaban | King |
| Scarlett Johansson | Nutmeg |
| Tilda Swinton | Oracle |
| Harvey Keitel | Gondo |
| Courtney B. Vance | Narrator |
| Greta Gerwig | Tracy Walker |
| Fisher Stevens | Scrap |
| Liev Schreiber | Spots |
| F. Murray Abraham | Jupiter |
| Frank Wood | Simul-Translate Machine |
| Yoko Ono | Yoko Ono-san |
Technical Credits
| Wes Anderson | Director,Original Story,Producer,Screenwriter |
| Ben Adler | Associate Producer |
| Douglas Aibel | Casting |
| Edward Bursch | Editor |
| Roman Coppola | Original Story |
| Jeremy Dawson | Producer |
| Alexandre Desplat | Score Composer |
| James Emmott | Asst. Director |
| Curt Enderle | Art Director |
| Christopher Fisser | Executive Producer |
| Ralph Foster | Editor |
| Tobias Fouracre | Animator |
| Paul Harrod | Production Designer |
| Henning Molfenter | Executive Producer |
| Kunichi Nomura | Casting,Original Story |
| Tristan Oliver | Cinematographer |
| John Peet | Associate Producer |
| Octavia Peissel | Co-producer |
| Randall Poster | Musical Direction/Supervision |
| Simon Quinn | Animator |
| Steven Rales | Producer |
| Scott Rudin | Producer |
| Jason Schwartzman | Original Story |
| Adam Stockhausen | Production Designer |
| Andrew Weisblum | Editor |
| Charlie Woebcken | Executive Producer |
