In this independent drama, a young man tries to find himself in the early 1970s as he wades through a swamp of heroin addiction. FH (Billy Crudup) is a well-intentioned but weak-willed man whose propensity for messing up his life has earned him his nickname, short for "F--khead." FH's problems with drugs begin in earnest when he falls in love with Michelle (Samantha Morton), a beautiful but emotionally unsettled woman addicted to heroin. FH soon finds himself drawn to the needle, and the couple drifts from one incident to the next, some funny and some horrifying. Michelle rescues FH from overdoses on a few occasions, although their friend Wayne (Denis Leary) isn't so lucky. After a few years, Michelle becomes pregnant and has an abortion in Chicago shortly before leaving FH and journeying to Mexico. While heading South in hopes of finding her, FH falls into a relationship with an older woman, Mira (Holly Hunter), and becomes involved in an auto wreck; his brush with death, and the opportunity to save a child's life, lead him into rehab and a chance to straighten out his life. The American debut from New Zealand director Alison Maclean and based on the novel by Denis Johnson, Jesus' Son also features Dennis Hopper, Will Patton, and Jack Black.