In this frantic black comedy, Harry Fishbine (Allen Garfield) is the proprietor of the F&B Ambulance Service, a low-budget free-lance rescue service which is struggling to keep up with the bigger and better funded competition after a law in Los Angeles decrees that the first ambulance to arrive at the scene of a distress call gets the job. F&B's best driver is Mother (Bill Cosby), a free-wheeling ambulance jockey who likes to drink beer and play dance music while he makes his rounds. Mother's new assistant is Speed (Harvey Keitel), a former cop who left the force after allegations of drug use; Speed is looking for a new career and a chance to prove himself. And Jugs is the accurate-if-sexist nickname for Jennifer (Raquel Welch), the company secretary who wants to get out from behind the desk and prove her skills as a paramedic. As F&B's drivers race through the streets of Hollywood, their adventures veer between the hilarious and the tragic. Mother, Jugs and Speed also features Larry Hagman, Dick Butkus, Bruce Davison, and L.Q. Jones.