| Ty Burrell | Mr. Peabody |
| Max Charles | Sherman |
| Stephen Colbert | Paul Peterson |
| Allison Janney | Ms. Grunion |
| Ariel Winter | Penny Peterson |
| Leslie Mann | Patty Peterson |
| Patrick Warburton | Agamemnon |
| Stanley Tucci | Leonardo da Vinci |
| Mel Brooks | Albert Einstein |
| Lake Bell | Mona Lisa |
| Zach Callison | King Tut |
| Dennis Haysbert | Judge |
| Stephen Tobolowsky | Principal Purdy |
| Laurie Fraser | Marie Antoinette,Egyptian Woman |
| Guillaume Aretos | Robespierre |
| Pat Musick | Teacher |
| Karan Brar | Mason |
| Joshua Rush | Carl |
| Steve Valentine | Ay |
| Leila Birch | WABAC Machine |
| Tom McGrath | Odysseus |
| Cullen McCarthy | Kid |
| Jasper Johannes Andrews | Baby Sherman |
| Walt Dohrn | French Peasant/Taxi Driver'Spartacus |
| Adam Alexi-Malle | French Peasant |
| Kim Bubbs | French Peasant |
| Nicholas Guest | French Peasant |
| Robert Cait | French Guard |
| Robert Ben Garant | Egyptian Spectator/Italian Peasant #1 |
| Thomas Lennon | Italian Peasant #2 |
| Rob Minkoff | Creepy Boy |
| Al Rodrigo | Ajax |
| Jess Harnell | Abraham Lincoln, George Washington, Bill Clinton,Isaac Newton, New York City Cop |
Technical Credits
| Rob Minkoff | Director |
| Nedy Acet | Animator |
| Drew Adams | Animator |
| Michael Andrews | Editor |
| André Araujo | Production Manager |
| Michael Babcock | Sound/Sound Designer |
| Christopher Martin Bancroft | Animator |
| Bailey Brent | Animator |
| David Burgess | Animator |
| Denise Nolan Cascino | Producer |
| Kenny Chung | Animator |
| Jason Clark | Executive Producer |
| Albert Colomer | Animator |
| Melanie Cordan | Animator |
| Denis Couchon | Animator |
| Holly Edwards | Associate Producer |
| Danny Elfman | Score Composer |
| Eric Ellenbogen | Executive Producer |
| Leslee Feldman | Casting |
| Christi Soper Hilt | Casting |
| David A.S. James | Production Designer |
| Richard King | Sound/Sound Designer |
| Dinesh Krishnan-Nair | Production Manager |
| Timothy J. Lamb | Art Director |
| Michael McCullers | Screenwriter |
| Matt Pomeroy | Production Manager |
| Alex Schwartz | Producer |
| Milind D. Shinde | Production Manager |
| Tiffany Ward | Executive Producer |
| Craig Wright | Screenwriter |
