Paradise Express is Grand Hotel out of Twentieth Century, fresh from the Republic Studio breeding farms. The titular express is a small-time freight service, struggling for survival against a larger, more streamlined rail company. Faced with bankruptcy, the owners of the underdog railroad challenge their competitors to a race, winner take all. Handsome Larry Doyle (Grant Withers) mans the controls of the Paradise Express, bearing a collection of familiar movie stereotypes. Featured in the cast is harmonica virtuoso Bob McClung, who earlier in 1937 provided off-screen assistance to Laurel and Hardy's "harmonica challenge" scene in Hal Roach's Pick a Star.