| Mary Steenburgen | Jessie Caldwell |
| Sean Patrick Flanery | Powder |
| Lance Henriksen | Sheriff Barnum |
| Jeff Goldblum | Donald Ripley |
| Brandon Smith | Duncan |
| Bradford Tatum | John Box |
| Susan Tyrrell | Maxine |
| Missy Crider | Lindsey |
| Ray Wise | Stipler |
| Esteban Powell | Mitch |
| Woody Watson | Mr. Kelloway |
| James Houston | Doc. Assoc. #1 |
| Alex Allen Morris | Dr. Roth |
| Brady Coleman | Dr. Deggan |
| Barry Berfield | Paramedic |
| Chad Cox | Zane |
| Paula Engel | Anna |
| Reed Frerichs | Syke |
| Bonnie Gallup | Nurse |
| Bill Grant-Minchen | Doctor Associate |
| Philip Maurice Hayes | Greg |
| Dee Macaluso | Nurse |
| Joe Marchman | Brennan |
| Dannete McMann | Emma |
| Tom Tarantini | Steven Barnum |
| Meason Wiley | Arturo |
Technical Credits
| Victor Salva | Director,Screenwriter |
| Steve Aaron | Sound/Sound Designer |
| William D. Barber | Camera Operator |
| Roger Birnbaum | Producer |
| Grodnik Birnbaum | Producer |
| Thomas R. Burman | Makeup |
| Betsy Cox | Costumes/Costume Designer |
| Bari Drieband-Burman | Makeup |
| Riley Kathryn Ellis | Executive Producer |
| Florence Fellman | Set Decoration/Design |
| Jerry Goldsmith | Score Composer |
| Nick Gomez | Stunts |
| Carol Louise Green | Asst. Director |
| Daniel Grodnik | Producer |
| Dennis M. Hill | Editor |
| Bob Ivy | Stunts |
| Waldemar Kalinowski | Production Designer |
| Barry Kingston | Art Director |
| Junie Lowry-Johnson | Casting |
| John Patrick McLaughlin | Stunts |
| Dennis Murphy | Co-producer |
| Robert Snukal | Executive Producer |
| Russell Towery | Stunts |
| Jerzy Zielinski | Cinematographer |