Rock Hudson stars in Seminole as 19th-century army officer Lance Caldwell. Born and raised in Florida, Caldwell is assigned to Fort King in the Everglades. Immediately clashing with his commanding officer Major Dade (Richard Carlson), Caldwell opposes Dade's plans to wipe out the Seminole Indians. The fact that Caldwell was the boyhood chum of Seminole chief Osceola (Anthony Quinn) is all the more reason to resist Dade's genocidal policies. After a deadly confrontation which costs dozens of lives on both sides, Osceola rescues Caldwell, whereupon the latter is court-martialed. Later on, Osceola comes to Fort King to talk peace, and is promptly killed by persons unknown. An attempt is made to frame Caldwell for the killing, but the truth eventually prevails. In the tradition of Broken Arrow, Seminole is essentially sympathetic to the Indian's point of view. Co-starring in the film are Barbara Hale as the requisite heroine and Lee Marvin as a surly sergeant.