The "six" are Charlie Ruggles, Mary Boland, George Burns, Gracie Allen, W.C. Fields, and Alison Skipworth, who star in this cross-country comedy. Planning a motor vacation to California, J. Pinkham Whinney (Ruggles) and Flora Whinney (Boland) advertise for a couple to help drive and share expenses. That couple turns out to be George Edwards (Burns) and Gracie De Vore (Allen), accompanied by Allen's surly Great Dane. Whinney is driven to near-insanity by Edwards' intrusiveness and stupidity, but the worst is yet to come: thanks to a crooked co-worker, Whinney has been accused of stealing bank funds and is now an unwitting fugitive from justice. Sheriff Hoxley (W.C. Fields, who spends a priceless ten minutes explaining why he's called "Honest John") joins forces with hotel proprietor Mrs. "Duchess" K. Rumford (Alison Skipworth) in hopes of capturing Whinney and claiming the reward. After a zany night of everybody in the cast running in and out of hotel rooms, the real crook is captured and Whinney and Flora prepare to enjoy what's left of their vacation.