Endocrine Disruptors and Puberty / Edition 1

by Evanthia Diamanti-Kandarakis, Andrea C. Gore

Overview

Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole.  Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.

Product Details

ISBN-13:	9781627039222
Publisher:	Springer-Verlag New York, LLC
Publication date:	03/03/2014
Series:	Contemporary Endocrinology
Edition description:	2012
Pages:	378
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

1 Introduction to endocrine disruptors and Puberty
  Evanthia Diamanti-Kandarakis
  Andrea C. Gore

Part I: EDCs, endocrine systems, and puberty  
2 In utero exposure to environmental chemicals - Lessons from maternal cigarette smoking and its effects on gonad development and puberty
  Rebecca McKinlay
  Peter O’Shaughnessey
  Richard M. Sharpe
  Paul A. Fowler

3 Reproductive Neuroendocrine Targets of Developmental Exposure to Endocrine Disruptors
  Sarah M. Dickerson
  Stephanie L. Cunningham
  Andrea C. Gore

4 Endocrine disruptors and puberty disorders from mice to men (and women)
  Alberto Mantovani

5 Thyroid hormone regulation of mammalian reproductive development and the potential impact of endocrine disrupting chemicals
  Kara Renee Thoemke
  Thomas William Bastian
  Grant Wesley Anderson

Part II: Developmental exposure to endocrine disruptors and adverse reproductive outcomes  
6 Developmental exposure to endocrine disruptors and ovarian function
  Evanthia Diamanti-Kandarakis
  Eleni Palioura
  Eleni A.Kandaraki

7 Developmental exposure to environmental endocrine disruptors and adverse effects on mammary gland development   
  Suzanne Fenton
  Lydia M. Beck
  Aditi R. Borde
  Jennifer Rayner

8 Developmental exposure to endocrine disruptors and male urogenital tract malformations
  Mariana F. Fernandez
  Nicolas Olea, MD PhD

9 EDC exposures and the development of reproductive and non-reproductive behaviors
  Amy B. Wisniewski
  Craige C. Wrenn
  Ashwini Mallappa

Part III. Developmental exposure to endocrine disruptors and metabolic disorders  
10 Adipocytes as target cells for endocrine disruption
  Amanda Janesick
  Bruce Blumberg

11 Altered Glucose Homeostasis Resulting From Developmental Exposures To Endocrine Disruptors
  Alan Schneyer
  Melissa Brown

12 Developmental Exposure to Endocrine Disrupting Chemicals: Is there a Connection with Birth and Childhood Weights?  
  Elizabeth E. Hatch
  Jessica W Nelson
  Rebecca Triosi
  Linda Titus

Part IV. EDCs and Human Health  
13 The Impact Of Endocrine Disruptors On Female Pubertal Timing
  Jean-Pierre Bourguignon
  Anne-Simone Parent

14 The influence of endocrine disruptors on Male Pubertal Timing
  Xiu-feng Wu
  Ningning Zhang
Mary M. Lee

15 Secular Trends in Pubertal Timing: A Role for Environmental Chemical Exposure?
  Vincent F. Garry
  Peter Truran, PhD

Editorial Reviews

From the reviews:

“This volume concentrates on the effects surrounding the pubertal process. … An important text for Public Health workers, but also to all physicians … .” (Pediatric Endocrinology Reviews (PER), Vol. 10 (2), 2013)

From the Publisher

Reviewer: Robert Michael Sargis, M.D., Ph.D.(University of Chicago Medical Center)
Description: This book details the impact of environmental endocrine disruptors, exogenous chemicals that modulate endogenous hormonal axes, on pubertal development. With strong roots in both human and animal data, it outlines the many emerging connections linking environmental insults to altered sexual development.
Purpose: The editors set out to provide a comprehensive analysis of the basic science and clinical literature linking endocrine disruptors with alterations in pubertal development. The changes in sexual maturation observed in the clinic warrant a careful exploration of all contributors to these significant changes. Thankfully, the editors and authors have done a masterful job in assembling the relevant data linking chemical exposures to pubertal development.
Audience: Although written for an academic audience with an interest in the impact of endocrine disruptors on human health as well as animal development, interested students and clinicians will find the work accessible. Educated lay audiences with an interest in this emerging field of endocrinology should be able to navigate this book.
Features: The editors have employed an excellent group of authors to contribute diverse chapters exploring the various perspectives on endocrine disruption of pubertal development. Included are chapters describing the evidence linking chemical exposures to alterations in human development as well as basic science chapters that define what is known about chemical effects on animal sexual development. The book's translational focus includes specific chapters that discuss the mouse-to-human spectrum of effects. The final section explores the implications of environmental pollutants on pubertal development by specifically examining the observed changes in pubertal timing over the last several decades. Collectively, these studies provide a comprehensive analysis of endocrine disruption of puberty.
Assessment: Changes in pubertal timing over the last several decades raise important questions about the effects of environmental pollutants on human health. Anyone interested in understanding how pubertal development can be disturbed by endocrine disruptors will find this book both incredibly interesting and very useful.

Doody's Review Service