Endothelin Receptors: From the Gene to the Human / Edition 1

Endothelin Receptors: From the Gene to the Human / Edition 1

by Robert R. Ruffolo, Jr.
ISBN-10:
0849359384
ISBN-13:
9780849359385
Pub. Date:
05/19/1995
Publisher:
Taylor & Francis
ISBN-10:
0849359384
ISBN-13:
9780849359385
Pub. Date:
05/19/1995
Publisher:
Taylor & Francis
Endothelin Receptors: From the Gene to the Human / Edition 1

Endothelin Receptors: From the Gene to the Human / Edition 1

by Robert R. Ruffolo, Jr.

Hardcover

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Overview

Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans.
This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.

Product Details

ISBN-13: 9780849359385
Publisher: Taylor & Francis
Publication date: 05/19/1995
Series: Handbooks in Pharmacology and Toxicology , #21
Edition description: New Edition
Pages: 304
Product dimensions: 6.12(w) x 9.19(h) x (d)

About the Author

Robert R. Ruffolo Jr.

Table of Contents

Introduction: Endothelin Receptors, E.H. Ohlstein and R.R. Ruffolo, Jr.Endothelin Receptor Subclassification, E.H. Ohlstein, P. Nambi, and R.R. Ruffolo, Jr.Molecular Biology of Endothelin Receptors, D.J. Bergsma, N. Elshourbagy, and C. Kumar Signal Transduction Processes Involved in Endothelin-Mediated Responses, P. Nambi, C. Kumar, and E.H. OhlsteinEndothelin Receptor Antagonists, J.D. Elliott, M.A. Lago, and C.E. PeishoffFunctions Mediated by Peripheral Endothelin Receptors, E.H. Ohlstein, S. Douglas, D.P. Brooks, D.W.P. Hay, G.Z. Feuerstein, and R.R. Ruffolo, Jr.Endothelin in the Central Nervous System, R.N. Willette, G.Z. Feuerstein, and F.C. BaroneThe Role of Endothelin in Human Disease: Implications and Potential Therapeutic Intervention, D.K. Jorkasky, D.W.P. Hay, and M.I. FreedIndex
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