Pub. Date:
Taylor & Francis
Endothelium-Derived Hyperpolarizing Factor / Edition 1

Endothelium-Derived Hyperpolarizing Factor / Edition 1

by Paul M. Vanhoutte


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Endothelium-Derived Hyperpolarizing Factor / Edition 1

Inspired by the First International Symposium on EDHF, held in Vaux de Cernayin in June 1995, this book presents the first comprehensive study of the factor. It introduces EDHF and its effects and discusses the nature of EDHF and the mechanisms underlying its release. It looks at the effects of EDHF on vascular smooth muscle and its potential contribution to the physiology of the vascular wall. Also investigated is the possible role of EDHF in human physiology and pathology.
Endothelium-dependent responses have been discovered in most vasculature of all species so far studied. The first factor to be isolated was termed 'endothelium-derived relaxing factor' and has been identified as nitric oxide. The search for another factor has lead to a likely candidate, dubbed 'endothelium-derived hyperpolarizing factor' (EDHF).

Product Details

ISBN-13: 9783718659296
Publisher: Taylor & Francis
Publication date: 12/13/1996
Series: Endothelial Cell Research Series
Edition description: New Edition
Pages: 368
Product dimensions: 7.00(w) x 10.00(h) x 0.94(d)

Table of Contents

Existence of Multiple Endothelium-Derived Relaxing Factors
Kinins and Endothelium-Dependent Hyperpolarizing in Porcine Coronary Arteries
Bioassay of a Cytochrome P450-Dependent Endothelial-Derived Hyperpolarizing Factor from Bovine Coronary Arteries
Calmodulin Inhibitors and Release of Endothelium-Derived Hyperpolarizing Factor in the Canine Coronary Artery
Cyclic Guanosine Monophosphate as a Hyperpolarizing Factor
Endothelium-Dependent Relaxation Resistant to L-Arginine Analogues in the Coronary Circulation
Imparied Endothelium-Dependent Hyperpolarization in the Mesenteric Artery of Spontaneously Hypertensive Rats

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