Enzyme Technologies: Metagenomics, Evolution, Biocatalysis and Biosynthesis / Edition 1

Enzyme Technologies: Metagenomics, Evolution, Biocatalysis and Biosynthesis / Edition 1

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Enzyme Technologies: Metagenomics, Evolution, Biocatalysis and Biosynthesis / Edition 1

An authoritative review of the latest developments in thechemical biology of enzymes

In the first decade of the twenty-first century, enzymes andtheir multiple applications have played a critical role in thediscovery and development of many new therapeutic agents.This bookis a coordinated compilation of research expertise and currentopinion uniquely focused on enzymes and their properties andapplications.

Compiled by editors with a combined pharmaceutical experience ofover sixty years, the text provides in-depth reviews of recentdevelopments in selective topics on biosynthesis, biocatalysis, andchemical biology of enzymes as it applies to drug discovery,development, and manufacture.

The first in a multi-part series on enzymes, this volumefeatures three sections:

  • New Approaches to Find and Modify Enzymes describes the emergingfield of metagenomics, presents the practical applications ofdirected evolution to enzymes and pathways, and explores approachesfor the discovery and design of biocatalysts

  • Biocatalytic Applications reviews specific applications ofdifferent reactions in producing active pharmaceutical ingredientsand surveys recent developments employing enzymes in organicsynthesis

  • Biosynthetic Applications goes over successful drug discoveriesand developments by combinatorial biosynthesis and reviews theapplication of combinatorial biosynthesis among multiple compatiblehosts

These timely discussions, which cover everything from chemicalbiology of enzymes, to the redesign of binding and catalyticspecificities of enzymes, make this volume a valuable tool forkeeping up to date. As such, it is an important read forresearchers, students, and professors in the study ofbiotechnology, life sciences, biochemistry, enzymology, medicinalchemistry, and natural products.

Product Details

ISBN-13: 9780470286241
Publisher: Wiley
Publication date: 09/21/2010
Series: Chemical Biology of Enzymes for Biotechnology and Pharmaceutical Applications Series , #1
Pages: 396
Product dimensions: 6.10(w) x 9.30(h) x 1.00(d)

About the Author

Wu-Kuang Yeh, PhD, is Executive Consultant and was directorof research and principal investigator at PreClinOmics, Inc., from2004–2010. He was a principal research scientist at Eli Lillyand Company from 1982–2004. He is the author or coauthor ofover 115 abstracts and publications, coeditor of one book, and theholder of six U.S. patents.

Hsiu-Chiung Yang, PhD, is a Research Advisor at Eli Lillyand Company. She was a principal research scientist at Eli Lillyand Company from 1998–2007 and is the author or coauthor ofover forty abstracts and publications, as well as co-inventor ofone patent.

James R. Mccarthy, PhD, is the author, coauthor, orcoeditor of over 125 scientific publications and holder of overforty U.S. patents. He is on the editorial advisory board of theJournal of Medicinal Chemistry and is a past chair of the divisionof Medicinal Chemistry of the American Chemical Society. He alsoserves as a Senior Scientific Advisor for the Huntington DiseaseResearch Foundation.

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Table of Contents

Contributors vii

Preface ix

Part A New Approaches to Finding and Modifying Enzymes 1

1 Functional Metagenomics as a Technique for the Discovery of Novel Enzymes and Natural Products Luke A. Moe Matthew D. McMahon Michael G. Thomas 3

2 Directed Enzyme and Pathway Evolution Jacob Vick Claudia Schmidt-Dannert 41

3 Combining Natural Biodiversity and Molecular-Directed Evolution to Develop New Industrial Biocatalysts and Drugs Laurent Fourage Céline Ayrinhac Johann Brot Christophe Ullmann Denis Wahler Jean-Marie Sonet 77

4 Principles of Enzyme Optimization for the Rapid Creation of Industrial Biocatalysts Richard J. Fox Lori Giver 99

Part B Biocatalytic Applications 125

5 Enzyme Catalysis in the Synthesis of Active Pharmaceutical Ingredients Animesh Goswami 127

6 Enzymatic Processes for the Production of Pharmaceutical Intermediates David Rozzell Jim Lalonde 185

7 Novel Developments Employing Redox Enzymes: Old Enzymes in New Clothes Kurt Faber Silvia M. Glueck Birgit Seisser Wolfgang Kroutil 199

Part C Biosynthetic Applications 251

8 Drug Discovery and Development by Combinatorial Biosynthesis Matthew A. DeSieno Carl A. Denard Huimin Zhao 253

9 Reprogramming Daptomycin and A54145 Biosynthesis to Produce Novel Lipopeptide Antibiotics Richard H. Baltz Kien T. Nguyen Dylan C. Alexander 285

10 Pathway and Enzyme Engineering and Applications for Glycodiversification Lishan Zhao Hung-wen Liu 309

Index 363

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