Enzymes of Lipid Metabolism

Enzymes of Lipid Metabolism

Paperback(Softcover reprint of the original 1st ed. 1978)

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Product Details

ISBN-13: 9781461590736
Publisher: Springer US
Publication date: 12/22/2012
Series: Advances in Experimental Medicine and Biology , #101
Edition description: Softcover reprint of the original 1st ed. 1978
Pages: 791
Product dimensions: 6.69(w) x 9.61(h) x 0.06(d)

Table of Contents

Enzymes Metabolizing Phospholipids: From Infancy to Middle Age (Plenary Lecture).- Enzymes of The Metabolism of Fatty Acids and Neutral Glycerides.- Fatty Acid Biosynthesis during Brain Development.- The Role of Soluble Acyl-Thioester Hydrolase in Fatty Acid Chain-Length Termination in Rabbit Mammary Gland and Liver.- Stereochemical Studies of Hydrogen Incorporation from Nucleotides with Fatty Acid Synthetase from Brevibacterium ammoniagenes.- Cholesterol Oxidase as a Probe for Studying Membrane Composition and Organization.- Adsorption and Activation of Pancreatic Lipase at Interfaces.- Mode of Action of Pancreatic Colipase.- Studies of Lipase and Phospholipase A2 Acting on Lipid Monolayers.- Inhibition of Lipase Adsorption at Interfaces Role of Bile Salts Micelles and Colipase.- Lipases of Rat Brain Microsomes.- Identification and Some Characteristics of the Enzyme Protein of the Hormone-Sensitive Lipase from Rat Adipose Tissue.- Affinity Chromatography on Heparin-Sepharose of Rat Adipose Tissue Triglyceride Lipase from Cytosol.- Enzymes of the Metabolism of Glycerophospholipids.- A) Phospholipases.- Relationship between Structure and Activity of Pancreatic Phospholipase A2.- Kinetic Anomalies Associated with Phospholipase A2 Hydrolysis of Micellar Substrates.- Mechanism of Phospholipase A2 Action Towards Mixed Micelles of Detergent and Phospholipids.- Chemical Modification of Crotalus atrox Phospholipase A2 by Means of a Photolabile Phosphatidylethanolamine Analog.- Phospholipases A of Krebs II Ascites Cells: Specificity, Release and Subcellular Localization.- Phospholipases of Plasmic Membranes of Adipose Tissue. Possible Intermediaries for Insulin Action.- Calcium-Activated Hydrolysis of Triphosphoinositide in Synaptosomes.- The Activity of Phospholipase D on Aggregates of Phosphatidylcholine, Dodecylsulfate and Ca2+.- The Preparation of Phospholipids by Phospholipase.- The Effects of Amphiphilic Compounds on Phosphatidate Metabolism.- B) Biosynthesis.- Choline and Ethanolamine Kinase Activity in the Cytoplasm of Nerve Endings from Rat Forebrain.- The Release of Free Ethanolamine in Rat Brain Homogenates Incubated in Krebs Ringer.- Ethanolamine and Choline Phosphotransferases of Chicken Brain.- Studies of Rat Brain Choline Ethanolamine Phosphotransferases Using Labeled Alkylacylglycerol as Substrate with Evidence for Reversibility of the Reactions.- The Role of Phosphatidylglycerol as a Donor of Phosphatidyl and of sn-Glycerol-l-Phosphate Groups in Biosynthetic Reactions.- Membrane-Bound Base-Exchange Reactions in Animal Tissues.- The “Base-Exchange” Reaction: The Serine Enzyme.- A Study on the Possible Occurrence of Base-Exchange Reactions in Vivo.- The Biosynthesis and Hormonal Regulation of Surfactant Formation.- Properties of a Lysophospholipase-Transacylase from Rat Lung: Its Possible Involvement in the Synthesis of Lung Surfactant.- A Study on the Turnover of Rat Brain Phosphatidic Acid through the Glycerol-Phosphate Pathway.- C) Ether Lipids.- Studies on the Biosynthesis of the O-Alkyl Bond in Glycerol Ether Lipids.- Asymmetric Localization of Alkyldihydroxyacetone-P Synthase and Acyldihydroxyacetone-P Acyltransferase in Microsomal Vesicles.- Studies on Soluble Proteins Stimulating Plamalogen Biosynthesis.- Pathway for Hydrolysis of Plasmalogens in Brain.- Turnover of Molecular Species of Diacyl and Alkyl Ether Phospholipids in Ehrlich Ascites Tumor Cells.- Enzymes of the Metabolism of Sphingolipids.- A) Neuraminidases.- Neuraminidase Gangliosides Interactions.- Action of Rat Brain Sialidase on Synaptic Membrane Components in situ.- Interaction of Human Brain Neuraminidase with Tritium-Labelled Gangliosides.- Studies on Bovine Brain Membrane-Bound Neuraminidase (Sialidase).- Intraneuronal Distribution of Cytosoluble Neuraminidase in Pig Brain.- B) Sphingomyelinases.- Effect of Detergents on the Utilization of Sphingomyelin by Brain Sphingomyelinases.- Sphingomyelinase of Human Tissues.- C) Glycolipid Hydrolases.- Purification and Partial Characterization of Human Liver ?-Galactosidase: Is ?-Galactosidase B an ?-N-Acetylgalactosaminidase?.- The Identity of ?-Galactosidase B from Liver.- Effect of Detergents on Ceramide-3 Hydrolysis by ?-Galactosidase A.- Specificity of Some Exo- and Endo-?-Galactosidases toward Glycosphingolipids.- Studies of Activity and Stability of Immobilized ?-N-Acetylhexosaminidase.- Affinity Methods for the Purification of Arylsulphatase A.- Existence, Localization and Some Properties of the Activators of Sphingolipid Hydrolases.- Studies on the Function of the Activator of Sulphatase A.- Glucosidase and Glucocerebrosidase Activity in Subcellular Fractions of Rat Spleen.- Inhibitors of ?-Glucosidases of Animal Tissues.- Isolation of Lysosomes from Bovine Brain Tissue. A New Zonal Centrifugation Technique.- D) Biosynthesis.- UDP-Galactose:Ceramide Galactosyltransferase. Kinetic Properties and Effect of Detergents and Phospholipids on the Partially Purified Enzyme of Rat Brain.- Isolation of an Endogenous Inhibitor of Ceramide Glycosyltransferases from Rat Brain.- Cellular Localization of Na+ K+-Dependent ATPase and of the Enzymes of Sulpholipid Metabolism in Rabbit Kidney.- Control of Ganglioside Biosynthesis by a Rate Limiting UMP-ase and Product Ganglioside Inhibition.- Studies on Retinal Ganglioside Metabolism.- Characteristics of the Brain Tissue Disialoganglioside G2a.- Formation of Glycosylated “Proteolipid-Like” Materials during Exogenous Protein Galactosylation by Human Body Fluids.- Enzymatic Aspects of the Lipid Storage Diseases.- Diagnoses of the Sphingolipidoses with Labelled Natural Substrates.- Assay of ?-Glucosidase and Sphingomyelinase for Identification of Patients and Carriers of Gaucher’s and Niemann Pick Diseases.- Hair Root Analysis in Heterozygotes for Fabry’s Disease.- Substrate Specificity of Hexosaminidase A Isolated from the Liver of a Patient with a Rare Form (AB Variant) of Infantile GM2 Gangliosidosis and Control Tissues.- Biochemical Studies in Sphingomyelin Storage Disorders.- Factors that Influence the Uptake and Turnover of Glucocerebrosidase and ?-Galactosidase in Mammalian Liver.- Enzyme Therapy XI: Immunologic Considerations for Replacement Therapy with Unentrapped, Erythrocyte- and Liposome-Entrapped Enzymes.- List of Participants.- Contributor Index.

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