Epithelial Transport and Barrier Function: Pathomechanisms in Gastrointestinal Disorders

Epithelial Transport and Barrier Function: Pathomechanisms in Gastrointestinal Disorders

by Jorg-Dieter Schulzke



Product Details

ISBN-13: 9781573312608
Publisher: New York Academy of Sciences
Publication date: 11/28/2000
Series: Annals of the New York Academy of Scienc
Pages: 375

Table of Contents

Part I.Expression of Transporters and Regulation of Ion Transport
Expression and Function of Na[superscript +]HCO[subscript 3 superscript -] Cotransporters in the Gastrointestinal Tract1
Characterization and Molecular Localization of Anion Transporters in Colonic Epithelial Cells15
Short-Term Regulation of NHE3 by EGF and Protein Kinase C but Not Protein Kinase A Involves Vesicle Trafficking in Epithelial Cells and Fibroblasts30
Cl-Dependent Na-H Exchange: A Novel Colonic Crypt Transport Mechanism43
Coupling between Na[superscript +], Sugar, and Water Transport across the Intestine54
Regulation of Chloride Secretion: Novel Pathways and Messengers67
Neurotransmitters in Neuronal Reflexes Regulating Intestinal Secretion77
Extended Abstracts
Three 5'-Variant mRNAs of Anion Exchanger AE2 in Stomach and Intestine of Mouse, Rabbit, and Rat81
Differential Regulation of ENaC by Aldosterone in Rat Early and Late Distal Colon92
Epithelial Phosphate Transporters in Small Ruminants95
Inflammatory Mediators Influencing Submucosal Secretory Reflexes98
Tumor Necrosis Factor-[alpha] Potentiates Ion Secretion Induced by Muscarinic Receptor Activation in the Human Intestinal Epithelial Cell Line HT29cl. 19A102
Investigation of Motility and Secretion in Perfused Guinea Pig Colon ex Situ107
Stimulation by Portal Insulin of Intestinal Glucose Absorption via Hepatoenteral Nerves and Prostaglandin E[subscript 2] in the Isolated, Jointly Perfused Small Intestine and Liver of the Rat111
Effects of HIV Protease Inhibitors on Barrier Function in the Human Intestinal Cell Line HT-29/B6117
Induction of Endothelial Barrier Function in Vitro123
Part II.Structure and Regulation of the Intestinal Barrier
The Structure and Function of Claudins, Cell Adhesion Molecules at Tight Junctions129
Intestinal Cell Adhesion Molecules: Liver-Intestine Cadherin136
Molecular Diversity of Plaques of Epithelial-Adhering Junctions144
Neutrophil Migration across Intestinal Epithelium151
Expression and Function of Death Receptors and Their Natural Ligands in the Intestine162
Role of M Cells in Intestinal Barrier Function171
Part III.Models for Studying Disturbed Transport and Barrier Properties
Nutrient Transporter Function Studied in Heterologous Expression Systems184
Epithelial Barrier Defects in HT-29/B6 Colonic Cell Monolayers Induced by Tumor Necrosis Factor-[alpha]193
Enhanced Expression of iNOS in Inflamed Colons of IL-2-Deficient Mice Does Not Impair Colonic Epithelial Barrier Function204
Regulation of Intercellular Tight Junctions by Zonula Occludens Toxin and Its Eukaryotic Analogue Zonulin214
Analysis of Low-Molecular-Weight GTP-Binding Proteins in Two Functionally Different Intestinal Epithelial Cell Lines223
Increased Tight Junction Permeability Can Result from Protein Kinase C Activation/Translocation and Act as a Tumor Promotional Event in Epithelial Cancers231
Stress-Induced Decrease of the Intestinal Barrier Function: The Role of Muscarinic Receptor Activation237
Immunologically Mediated Transport of Ions and Macromolecules247
Extended Abstracts
Carbachol-Induced Ca[superscript 2+] Entry into Rat Colonic Epithelium260
Effects of Endotoxin on Human Large Intestine264
Increased Paracellular Macromolecular Transport and Subnormal Glucose Uptake in Duodenal Biopsies of Patients with Microvillus Inclusion Disease: Comparisons to Other Chronic Diarrhea Patients and to Non-diarrhea Patients267
Apoptosis and Intestinal Barrier Function270
p53-Independent Apoptosis Induced by Menadione in the Human Colon Carcinoma Cell Line Caco-2275
Epidermal Growth Factor, Polyamines, and Epithelial Remodeling in Caco-2 Cells279
Effect of TNF[alpha] and IFN[gamma] on Epithelial Barrier Function in Rat Rectum in Vitro282
Colectomy and Ileal Pouch: Transport and Barrier in Pouchitis287
Part IV.Diarrheal Mechanisms in Gastrointestinal Diseases
Mechanisms of Epithelial Barrier Impairment in HIV Infection293
Cytokine-Induced Alteration of the Epithelial Barrier to Food Antigens in Disease304
Epithelial Barrier and Transport Function of the Colon in Ulcerative Colitis312
Diarrhea in Ulcerative Colitis: The Role of Altered Colonic Sodium Transport327
Barrier Dysfunction and Crohn's Disease333
Mechanisms of Cholera Toxin-Induced Diarrhea339
Effects of Clostridium difficile Toxins on Epithelial Cell Barrier347
Ion Transport during Growth and Differentiation357
Index of Contributors373

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