ISBN-10:
0309059313
ISBN-13:
9780309059312
Pub. Date:
01/19/1998
Publisher:
National Academies Press

Paperback

Current price is , Original price is $53.0. You

Temporarily Out of Stock Online

Please check back later for updated availability.

This item is available online through Marketplace sellers.

Overview

This book assesses the scientific value and merit of research on human genetic differences—including a collection of DNA samples that represents the whole of human genetic diversity—and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.


Product Details

ISBN-13: 9780309059312
Publisher: National Academies Press
Publication date: 01/19/1998
Edition description: New Edition
Pages: 102
Product dimensions: 6.00(w) x 9.00(h) x 0.27(d)

Table of Contents

EXECUTIVE SUMMARY 1(9)
Sampling Issues 2(3)
Sample Collection and Data Management 5(1)
Human Rights Considerations 6(2)
Organization and Management 8(2)
1 INTRODUCTION AND BACKGROUND
10(6)
The Committee, Its Charge, and Its Activities
11(1)
The Proposed Human Genome Diversity Project
12(2)
This Report
14(2)
2 SCIENTIFIC AND MEDICAL VALUE OF RESEARCH ON HUMAN GENETIC VARIATION
16(7)
Human History and Evolution
17(2)
Basic Mechanisms of Genome Evolution
19(1)
Biomedical Applications
20(2)
Conclusion
22(1)
3 SAMPLING ISSUES
23(13)
Basic Sampling Strategies
24(1)
Strategies That Are Not Population Based
25(1)
Strategies That Are Population Based
25(5)
Which Sampling Strategy Should Be Used?
30(2)
How to Select Which Human Populations to Sample
32(1)
Considerations in Choosing Subject Populations
32(1)
Number of Populations to Sample, and Number of People to Sample in a Population
33(2)
Summary and Conclusions
35(1)
4 SAMPLE COLLECTION AND DATA MANAGEMENT
36(19)
Sources of DNA to Be Sampled
36(3)
Characterization of Genetic Variation
39(1)
Classes of DNA Markers
40(2)
DNA Polymorphisms Based on Single Nucleotide Substitutions
42(1)
Should There Be a Core Set of DNA Markers That Will Be Scored for All Samples in the Repository?
43(1)
Research-Materials Management
44(3)
Data Management
47(2)
Functional Requirements for Human Genetic Variation Data
49(1)
Data Acquisition Methods
50(1)
Quality Control and Annotation
50(1)
Communication Via Public Networks
51(1)
Archival Storage
51(1)
Distribution and Access
52(1)
Security Issues Related to Human Genetic Variation Data
52(1)
Summary and Conclusions
53(2)
5 HUMAN RIGHTS AND HUMAN GENETIC-VARIATION RESEARCH
55(14)
Context of Concerns About Studying Human Genetic Variation
56(2)
Ethical Considerations in the Design of Human Genetic-Variation Research
58(7)
Control
65(1)
Commercialization and Reciprocity Agreements
66(2)
Conclusion
68(1)
6 ORGANIZATIONAL AND OTHER ISSUES
69(5)
REFERENCES 74(7)
APPENDIX A: Committee on Human Genome Diversity: Biographical Information 81(8)
APPENDIX B: Acknowledgments 89

Customer Reviews

Most Helpful Customer Reviews

See All Customer Reviews