Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology / Edition 1

Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology / Edition 1

ISBN-10:
0470044918
ISBN-13:
9780470044919
Pub. Date:
01/19/2010
Publisher:
Wiley

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Overview

Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology / Edition 1

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation

It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development.

Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:

  • Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics

  • Address developability issues that challenge pharma companies, moving beyond isolated experimental results

  • Reveal connections between the key scientific areas that are critical for successful drug discovery and development

  • Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace

Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.

Product Details

ISBN-13: 9780470044919
Publisher: Wiley
Publication date: 01/19/2010
Series: Wiley Series in Drug Discovery and Development Series , #12
Pages: 289
Product dimensions: 6.30(w) x 9.30(h) x 0.90(d)

Table of Contents

Preface vii

Contributors ix

1 Introduction Charles B. Davis 1

2 Pharmacokinetics in Preclinical Drug Development: An Overview Dion Brocks 11

3 The Role of Membrane Transporters in Drug Disposition Fanfan Zhou Peng Duan Guofeng You 39

4 Cytochrome P450: Structure, Function, and Application in Drug Discovery and Development Ramesh B. Bambal Stephen E. Clarke 55

5 The Role of Drug Metabolism and Metabolite Identification in Drug Discovery Xiangming Guan 109

6 Protein Binding in Drug Discovery and Development Vikram Ramanathan Nimish Vachharajani 135

7 Prediction of the Pharmacokinetics in Humans Chao Han Ramesh Bambal 169

8 Pharmaceutics Developability Assessment Lian Huang Jinquan Dong Shyam Karki 187

9 Safety Assessment in Drug Discovery Vito G. Sasseville William R. Foster Bruce D. Car 221

10 Assessment Of Strategies Utilized to Minimize the Potential For Induction of Acquired Long QT Syndrome and Torsade De Pointes Khuram W. Chaudhary Barry S. Brown 253

Index 281

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