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Experimental Cholestasis Research

Experimental Cholestasis Research

by Mathieu Vinken (Editor)

Hardcover(1st ed. 2019)

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Product Details

ISBN-13: 9781493994199
Publisher: Springer New York
Publication date: 06/02/2019
Series: Methods in Molecular Biology , #1981
Edition description: 1st ed. 2019
Pages: 438
Product dimensions: 7.01(w) x 10.00(h) x (d)

Table of Contents

1. Mechanisms of Drug-Induced Cholestasis


Eva Gijbels and Mathieu Vinken



2. LC-MS/MS Analysis of Bile Acids in In Vitro Samples


Debbie Dewaele, Pieter Annaert, and Eef Hoeben




3. Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis


Amruta Damle-Vartak, Brigitte Begher-Tibbe, Georgia Gunther, Fabian Geisler, Nachiket Vartak, and Jan G. Hengstler



4. Vesicle-Based and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Function


Pieter Van Brantegem, Neel Deferm, Bing Qi, Tom De Vocht, and Pieter Annaert



5. The C-DILI™ Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity


Jonathan P. Jackson and Kenneth R. Brouwer



6. In Vivo Measurement of Hepatic Drug Transporter Inhibition with Radiolabeled Bile Acids


Stef De Lombaerde, Sara Neyt, Christian Vanhove, and Filip De Vos



7. Measuring the Impact of Bile Acids on the Membrane Order of Primary Hepatocytes and Isolated Mitochondria by Fluorescence Imaging and Spectroscopy


Tânia Sousa, Rui E. Castro, Ana Coutinho, Cecília M.P. Rodrigues, Manuel Prieto, and Fábio Fernandes



8. The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis


Reza Heidari and Hossein Niknahad



9. Measuring Apoptosis and Necrosis in Cholestatic Liver Injury


Benjamin L. Woolbright and Hartmut Jaeschke



10. Necrosome Formation and Necroptosis in Experimental Cholestasis


Marta Bento Afonso and Cecília Maria Pereira Rodrigues



11. Proteomics in Primary Biliary Cholangitis


You Li, Ruqui Tang, Patrick S.C. Leung, Eric Gershwin, and Xiong Ma



12. Transcriptomics Analysis of Cholestatic Compounds In Vitro


Céline Parmentier, Philippe Couttet, Marianne Uteng, Armin Wolf, and Lysiane Richert



13. Systems Microscopy of Stress Response Pathways in Cholestasis Research


Johannes P. Schimming, Bas ter Braak, Marije Niemeijer, Steven Wink, and Bob van de Water



14. Mouse Models for Diseases in the Cholangiocyte Lineage


Noémi Van Hul, Urban Lendahl, and Emma R. Andersson



15. Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis


Sanne Van Campenhout, Hans Van Vlierberghe, and Lindsey Devisscher



16. 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine Diet: A Rodent Model in Cholestasis Research


Elisa Pose, Pau Sancho-Bru, and Mar Coll



17. A Rotavirus-Induced Mouse Model to Study Biliary Atresia and Neonatal Cholestasis


Sujit K. Mohanty, Bryan Donnelly, Haley Temple, and Gregory M. Tiao



18. Zebrafish as a Model to Study Cholestatic Liver Diseases


Duc-Hung Pham and Chunyue Yin



19. Set-Up and Use of HepaRG Cells in Cholestasis Research


Christiane Guguen-Guillouzo and André Guillouzo



20. Organotypic 3D HepaRG Liver Model for Assessment of Drug-Induced Cholestasis


Sreenivasa C. Ramaiahgari and Stephen S. Ferguson



21. Establishment of Sandwich Cultures of Primary Human Hepatocytes


Eva Gijbels, Tamara Vanhaecke, and Mathieu Vinken



22. Detection of Drug-Induced Cholestasis Potential in Sandwich-Cultured Human Hepatocytes


Neel Deferm, Lysiane Richert, Pieter Van Brantegem, Tom De Vocht, Bing Qi, Peter de Witte, Thomas Bouillon, and Pieter Annaert



23. Ex Vivo Model in Cholestasis Research


Ruby E.H. Karsten, Dorenda Oosterhuis, Louise A. van Wijk, and Peter Olinga



24. Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies


Carol J. Soroka, David N. Assis, and James L. Boyer



25. Use of Biliary Organoids in Cholestasis Research


Fotios Sampaziotis, Olivia Tysoe, Teresa Brevini, and Ludovic Vallier



26. In Silico Approaches to Predict Drug-Transporter Interaction Profiles: Data Mining, Model Generation, and Link to Cholestasis


Sankalp Jain and Gerhard F. Ecker