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Experimental Cholestasis Research

Experimental Cholestasis Research

by Mathieu Vinken (Editor)

Hardcover(1st ed. 2019)

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Product Details

ISBN-13: 9781493994199
Publisher: Springer New York
Publication date: 06/02/2019
Series: Methods in Molecular Biology , #1981
Edition description: 1st ed. 2019
Pages: 438
Product dimensions: 7.01(w) x 10.00(h) x (d)

Table of Contents

1. Mechanisms of Drug-Induced Cholestasis

Eva Gijbels and Mathieu Vinken

2. LC-MS/MS Analysis of Bile Acids in In Vitro Samples

Debbie Dewaele, Pieter Annaert, and Eef Hoeben

3. Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis

Amruta Damle-Vartak, Brigitte Begher-Tibbe, Georgia Gunther, Fabian Geisler, Nachiket Vartak, and Jan G. Hengstler

4. Vesicle-Based and Hepatocyte-Based Assays for Identification of Drug Candidates Inhibiting BSEP Function

Pieter Van Brantegem, Neel Deferm, Bing Qi, Tom De Vocht, and Pieter Annaert

5. The C-DILI™ Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity

Jonathan P. Jackson and Kenneth R. Brouwer

6. In Vivo Measurement of Hepatic Drug Transporter Inhibition with Radiolabeled Bile Acids

Stef De Lombaerde, Sara Neyt, Christian Vanhove, and Filip De Vos

7. Measuring the Impact of Bile Acids on the Membrane Order of Primary Hepatocytes and Isolated Mitochondria by Fluorescence Imaging and Spectroscopy

Tânia Sousa, Rui E. Castro, Ana Coutinho, Cecília M.P. Rodrigues, Manuel Prieto, and Fábio Fernandes

8. The Role and Study of Mitochondrial Impairment and Oxidative Stress in Cholestasis

Reza Heidari and Hossein Niknahad

9. Measuring Apoptosis and Necrosis in Cholestatic Liver Injury

Benjamin L. Woolbright and Hartmut Jaeschke

10. Necrosome Formation and Necroptosis in Experimental Cholestasis

Marta Bento Afonso and Cecília Maria Pereira Rodrigues

11. Proteomics in Primary Biliary Cholangitis

You Li, Ruqui Tang, Patrick S.C. Leung, Eric Gershwin, and Xiong Ma

12. Transcriptomics Analysis of Cholestatic Compounds In Vitro

Céline Parmentier, Philippe Couttet, Marianne Uteng, Armin Wolf, and Lysiane Richert

13. Systems Microscopy of Stress Response Pathways in Cholestasis Research

Johannes P. Schimming, Bas ter Braak, Marije Niemeijer, Steven Wink, and Bob van de Water

14. Mouse Models for Diseases in the Cholangiocyte Lineage

Noémi Van Hul, Urban Lendahl, and Emma R. Andersson

15. Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis

Sanne Van Campenhout, Hans Van Vlierberghe, and Lindsey Devisscher

16. 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine Diet: A Rodent Model in Cholestasis Research

Elisa Pose, Pau Sancho-Bru, and Mar Coll

17. A Rotavirus-Induced Mouse Model to Study Biliary Atresia and Neonatal Cholestasis

Sujit K. Mohanty, Bryan Donnelly, Haley Temple, and Gregory M. Tiao

18. Zebrafish as a Model to Study Cholestatic Liver Diseases

Duc-Hung Pham and Chunyue Yin

19. Set-Up and Use of HepaRG Cells in Cholestasis Research

Christiane Guguen-Guillouzo and André Guillouzo

20. Organotypic 3D HepaRG Liver Model for Assessment of Drug-Induced Cholestasis

Sreenivasa C. Ramaiahgari and Stephen S. Ferguson

21. Establishment of Sandwich Cultures of Primary Human Hepatocytes

Eva Gijbels, Tamara Vanhaecke, and Mathieu Vinken

22. Detection of Drug-Induced Cholestasis Potential in Sandwich-Cultured Human Hepatocytes

Neel Deferm, Lysiane Richert, Pieter Van Brantegem, Tom De Vocht, Bing Qi, Peter de Witte, Thomas Bouillon, and Pieter Annaert

23. Ex Vivo Model in Cholestasis Research

Ruby E.H. Karsten, Dorenda Oosterhuis, Louise A. van Wijk, and Peter Olinga

24. Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies

Carol J. Soroka, David N. Assis, and James L. Boyer

25. Use of Biliary Organoids in Cholestasis Research

Fotios Sampaziotis, Olivia Tysoe, Teresa Brevini, and Ludovic Vallier

26. In Silico Approaches to Predict Drug-Transporter Interaction Profiles: Data Mining, Model Generation, and Link to Cholestasis

Sankalp Jain and Gerhard F. Ecker