Experimental Hepatocarcinogenesis

Experimental Hepatocarcinogenesis

Paperback(Softcover reprint of the original 1st ed. 1988)

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Product Details

ISBN-13: 9781461282648
Publisher: Springer US
Publication date: 01/19/2012
Edition description: Softcover reprint of the original 1st ed. 1988
Pages: 332
Product dimensions: 6.69(w) x 9.61(h) x 0.03(d)

Table of Contents

Experimental and Human Liver Carcinogenesis: Cause and Modulation.- Hepatocarcinogens.- The Induction of Localized Tumors by Carcinogens Implanted into the Liver.- Two Stage Theory of Carcinogenesis: a critical review Introducing the Concept of Modulation.- Modulating Factors of Hepatocarcinogenesis.- Sex Hormones as Modulators of Liver Tumor Development.- Liver Cancer and Viruses.- Morphological Alterations During Liver Carcinogenesis.- Metabolic Zonation of the Liver.- Cellular Differentiation during Neoplastic Development in the Liver.- Histochemical Analysis of Hepatocarcinogenesis.- Cell Proliferation, Cell Death and Liver Carcinogenesis.- Cell Proliferation and Hepatocarcinogenesis.- Initiation of Chemical Hepatocarcinogenesis: Compensatory Cell Proliferation versus Mitogen Induced Hyperplasia.- Cell Death (Apoptosis) in Normal and Preneoplastic Liver Tissue.- Biochemical Alterations During Liver Carcinogenesis.- A Study of the Activities of Carbohydrate Metabolizing. Enzymes and the Levels of Carbohydrate Metabolites and Amino Acids in Normal Liver and in Hepatocellular Carcinoma.- The Expression of Cell Surface Receptors in Regenerating and Neoplastic Liver Tissue.- Cholesterol Metabolism during Cell Proliferation.- Mechanism of the Inhibition of Liver Carcinogenesis Promotion by S-adenosyl-L-methionine.- Nuclear and Genetic Alterations During Liver Carcinogenesis.- Long Term Effect of Diethylnitrosamine (DEN) on the Production of Micronuclei in Precancerous Rat Liver.- Nuclear Alterations during Hepatocarcinogenesis: Promotion by 2-acetylaminofluorene.- Cytogenetic and Genetic Alterations during Hepatocarcinogenesis.- Role of Oncogenes in Hepatocarcinogenesis.- In Vitro Studies in Liver Carcinogenesis.- Separation and Biochemical Characterization of Rat Liver Parenchymal Cell Subpopulations.- Growth Control of Hepatocytes, their Immortalization and Transformation by Transforming Genes of Polyoma Virus and of SV40 Virus.- Changes in Hepatocyte TGF? Receptors and Gene Expression during Normal and Neoplastic Liver Growth.- Regulation of Carbohydrate Metabolism in a Glycogenstoring Liver Cell Line.- Techniques in Measuring DNA Synthesis and Mitosis Induced by Tumor Promoters in Hepatocytes Primary Cultures.- Conclusions.- Concluding Remarks.- Contributors.

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