Familial Cancer and Prevention: Molecular Epidemiology - A New Strategy Toward Cancer Control / Edition 1 available in Hardcover
- Pub. Date:
A New Strategy Toward Cancer Control.Still in its infancy, the familial/hereditary approach to cancercontrol is proving to be one of the most potent strategies in thewar on cancer. Over the past few years the human genome project hasgenerated an abundance of valuable information on the geneticorigins of a range of cancers. Tests now exist for severalhereditary, tumor-promoting genetic mutations-including those foundin BRCA genes associated with breast cancer as well as mutations ofHNPCC genes which have been linked to colon cancers-and many moreare anticipated in the near future. Armed with the informationyielded by these tests, physicians have already saved countlesslives through preventative counseling, early detection, and morehighly-focused intervention strategies.Inspired by the proceedings of the UICC 1997 Symposium on FamilialCancer and Prevention held in Kobe, Japan, this volume providesclinicians and researchers with a detailed review of the latestdevelopments at the front lines of the familial cancer preventionmovement. In a series of edited contributions, leading researchersand clinicians from around the globe summarize their experiencesand analyze current and emerging trends in:* Information gathering and history taking.* Risk assessment.* Genetic testing for colorectal, endocrine, breast, and otherfamilial cancers.* Diagnosis, prognosis, and management of an array of familialcancers.* Genetic counseling for familial cancers.Up-to-date, authoritative, and comprehensive, Familial Cancer andPrevention is an important working resource for clinicians, cancerresearchers, and epidemiologists.
Table of Contents
Partial table of contents:OVERVIEWS.The UICC Familial Cancer and Prevention Project (W. Weber).Molecular Epidemiology of Human Cancer (S. Hussain & C.Harris).GENERAL STRATEGIES AND EXPERIENCE.From Nurse to Nodal Points: The Rationale of a Questionnaire andDatabase to Collect, Validate, and Exchange Information on FamilialCancer (D. Brunetti & W. Weber).Collecting Information About Familial Cancer (W. Weber, etal.).Family History-Based Screening for Colorectal Cancer (D. St.John).Hereditary Tumor Registry in Korea (J.-G. Park).Ethical Issues in Precancer Screening: The Parallel With HuntingtonDisease (D. Dickenson).Bioethical Concerns With Rights of Patients Receiving Genetic Tests(K. Hoshino).Use of Genetic Information by Private Insurers (R. Pokorski).SPECIFIC FAMILIAL CANCERS.Surgical Management of Familial Adenomatous Polyposis (J.Utsunomiya & N. Gondo).Extracolonic Symptoms of Familial Adenomatous Polyposis and TheirAssociation With a Slow Acetylation Phenotype (R. Scott, etal.).Defining the Clinical Phenotype of Hereditary NonpolyposisColorectal Cancer (N. Beck, et al.).Evolution of Neoplasia in Hereditary Nonpolyposis Colorectal Cancer(J. Jass).Surveillance and Management of Hereditary Nonployposis ColorectalCancer (H. Vasen, et al.).Genetic Diagnosis and Management of Suspected HereditaryNonpolyposis Colorectal Cancer (J.-G. Park, et al.).The Impact of Living With Hereditary Colorectal Disease (T.Berk).Familial Colorectal Cancer in India: The Tata Memorial HospitalExperience (K. Mohandas).Nationwide Survey and Analysis of the RET Proto-Oncogene inInherited Medullary Thyroid Carcinoma in Japan (H. Takami).Management of Hereditary Medullary Thyroid Carcinoma (J. Moley& S. Wells).Mapping of Non-BRCA1/2 Breast Cancer Genes (Y. Shugart, etal.).Cancer Risk-Modifying Factors in BRCA1 or BRCA2 Mutation Carriers(T. Rebbeck).Hereditary Multiple Exostoses and Cancer Risk (D. Porter & A.Simpson).WORKSHOP REPORTS.UICC Molecular Biology Workshop Report (R. Scott).Workshop Report 1 (C. Harris).POSTER SESSIONS.