Pub. Date:
Springer Berlin Heidelberg
Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells / Edition 1

Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells / Edition 1

by Katharina Spanel-Borowski


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Product Details

ISBN-13: 9783642160769
Publisher: Springer Berlin Heidelberg
Publication date: 12/24/2010
Series: Advances in Anatomy, Embryology and Cell Biology , #209
Edition description: 2011
Pages: 110
Product dimensions: 6.10(w) x 9.10(h) x 0.40(d)

Table of Contents

1 Background.- 1.1 Innate Immunity, Toll-like Receptors (TLR), and Danger Signals 1.2 The Ovary, Tissue Remodelling, and Immune Privilege.- 1.3 Design.- 2 Material and Methods.- 2.1 Cyclic and Superovulated Ovaries from Rats, Hamsters, Rabbits as well as Canine, Bovine and Human Ovaries.- 2.1.1 Fibrinolytic Activity and Implants on the Chick Chorioallantoic Membrane (CAM).- 2.1.2 Fixation, Staining and Counting Ovarian Structures.- 2.2 Cell Culture Subtypes from Follicles Derived from Patients Under in Vitro Fertilization Therapy.- 2.3 Cell Culture Subtypes from Bovine Corpus Luteum (CL) and Characterization.- 3 Footmarks of Innate Immunity.- 3.1 The Complement System as Danger Sensor in General and in the Ovary.- 3.2 Mild Danger with Mild Response.- 3.2.1 Implantation of the Ovary into the CAM.- 3.2.2 Follicular Atresia.- 3.3 Moderate Danger by Preovulatory Follicle Rupture and Acute Inflammation with Eosinophils.- 3.3.1 Recruitment of Eosinophils and Substance P-Like Expression.- 3.4 Severe Danger in Superovulated Ovaries with Intra-Ovarian Oocyte Release and Thrombus Formation.- 4 Cytokeratin-Positive (CK+) cell as Potential Dendritic Cells.- 4.1 Dendritic cells, the TLR System in General and in the Ovary.- 4.2 Localisation of CK+ Cells in the Intact Ovary.- 4.2.1 Follicles in Foetal and Adult Ovaries.- 4.2.2 Corpus Luteum.- 5 Characterization of Isolated CK+ Cells.- 5.1 CK+ Cells from Preovulatory Follicles with TLR4 Expression.- 5.2 CK+ Cells from CL in Comparison to CK-Negative (CK-) Cells.- 5.2.1 Effects of Interferon-gamma on CK+ Cells from the CL Compared to CK- Cells and to Surface Epithelial Cells.- 5.2.2 Reflections on Quality of the CK+ Type 1 and Similarity with the Type 5.- 6 Working Hypothesis and Challenges.- 7 Clinical Perspectives.- 8 Concluding Summary and Remarks.- References.- Subject index

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