Pub. Date:
Elsevier Science & Technology Books
Forensic DNA Typing: Biology and Technology Behind STR Markers / Edition 1

Forensic DNA Typing: Biology and Technology Behind STR Markers / Edition 1

by John M. Butler


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Forensic DNA Typing examines the science of current forensic DNA typing methods by focusing on the biology and technology

ehind short tandem repeat (STR) markers and the most common forensic DNA analysis methods used today. This comprehensive handbook will help forensic scientists gain a better understanding of STRs, and help professionals in the law enforcement and legal communities comprehend the complexities of DNA profiling. It will also help forensic DNA laboratories meet the training requirements in the new DNA Advisory Board Quality Assurance Standards, which are reprinted in the Appendices.

The first few chapters of Forensic DNA Typing provide a thorough introduction to the topic for those readers who might be less

familiar with DNA, while providing a useful review for more advanced readers. It goes on to cover new genetic markers and information on rapidly changing technologies to help professionals understand how to make accurate identifications through DNA typing. The book concludes with reviews of the DNA testing performed in high-profile cases such as the O.J. Simpson trial, the President Clinton-Monica Lewinsky affair, identifying the remains of Russia's Romanov family and the Tomb of the Unknown Soldier, the Thomas Jefferson-Sally Hemings affair, and others.

Key Features:

* Provides a comprehensive look at the biology, technology, and applications of DNA typing

* Focuses on the major molecular biological technique currently being used throughout the world

* Uses a wide array of illustrations and examples to make the material easy to understand

* Progresses from basic introductory information to cutting-edge research

* Designed for forensic scientists, law enforcement and legal professionals, and students in related fields

* Provides DNA analysts with all the reported alleles for the 13 CODIS STR loci, including sizes and sequences

* Includes the DNA Advisory Board Quality Assurance Standards that pertain to DNA testing labs and convicted offender

* DNA databasing labs in the U.S.

* Reviews DNA testing performed in high-profile cases

Product Details

ISBN-13: 9780121479510
Publisher: Elsevier Science & Technology Books
Publication date: 04/28/2001
Edition description: Older Edition
Pages: 322
Product dimensions: 7.69(w) x 9.98(h) x 0.89(d)

Table of Contents

1. Overview and History of DNA Typing


2. DNA Biology Review

3. Sample Collection and Preparation (DNA Extractions and Quantification)

4. The Polymerase Chain Reaction (DNA Amplifications)

5. Commonly Used Short Tandem Repeat Markers

6. Biology of STRs: Stutter Products, Non-Template Addition, Microvariants, Null Alleles, and Mutation Rates

7. Forensic Issues: Degraded DNA, PCR Inhibition, Contamination, and Mixed Samples

8. Additional DNA Markers: Amelogenin, Y-Chromosome STRs,, mtDNA, SNPs, Alu Repeats


9. DNA Separation Methods: Slab-Gel and Capillary Electrophoresis

10. DNA Detection Methods: Fluorescent Dyes and Silver Staining

11. The ABI Prism 310 Genetic Analyzer

12. The Hitachi FMBIO II Fluorescence Imaging System

13. STR Genotyping Issues

14. Laboratory Validation

15. New Technologies and Automation

16. Combined DNA Index System (CODIS) and the Use of DNA Database

Biology, Technology and Genetics

17. DNA Testing in High-Profile Cases

Appendix I: Reported STR Alleles: Sizes and Sequences

Appendix II: CEPH Family History

Appendix III: DNA Advisory Board Quality Assurance Standards

Appendix IV: Suppliers of DNA Analysis Equipment, Products, or Services


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