From Basic Immunology to Immune-Mediated Demyelination

From Basic Immunology to Immune-Mediated Demyelination

Paperback(Softcover reprint of the original 1st ed. 1999)

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Overview

From Basic Immunology to Immune-Mediated Demyelination by Gianvito Martino

This book covers the immunological and clinical aspects of central and peripheral nervous system inflammatory diseases characterized by myel in damage. Leading scientists in the field have summarized in short re views the state of the art of neuroimmunology, with particular emphasi s on basic aspects of the regulation of immune responses during demyel inating disorders. The volume will be helpful to neuroimmunologists, b ut also to clinicians which will find a clear and concise understandin g of the main features of neuroinflammatory disease.

Product Details

ISBN-13: 9788847021792
Publisher: Springer Milan
Publication date: 10/08/2012
Series: Topics in Neuroscience
Edition description: Softcover reprint of the original 1st ed. 1999
Pages: 315
Product dimensions: 6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

Protective versus harmful responses and immune regulation Organization of the immune system antigen recongnition and autoimmunity Assembly and function of immunoglobulines during B cell development Immunological tolerance Pathogenetic mechanisms of autoimmunity Adhesion receptors involved in leukocyte functions The endothelium of the brain microvasculature and the organization of intercellular junction Chemokine and chemokine receptors The1/Th2 cytokine network Lymphocyte trafficking in the central nervous system Antigen presentation in the central nervous system Adhesion molecules and the blood-brain-barrier in multiple sclerosis Myelination steps in the central nervous system Genomic screen in multiple slerosis MHC and multiple sclerosis Cytokine genes in multiple sclerosis Non-myelin antigen autoreactivity in multiple sclerosis Myelin antigen autoreactivity in multiple sclerosis Inflammation and demyelination Magnetic resonance and blood-brain barrier dysfunction in multiple sclerosis Immunotherapies for multiple sclerosis Animal models of demyelination of the central nervous system MHC and non MHC genetics of rat EAE Genetic of hereditary neuropathies Animal models of demyelination in the PNS Immune-mediated neuropathies: diagnostic procedures Pathology of demyelination neuropathies Immunopathogenetic role of anti-neural antibodes in demyelinating dysimmune neuropathies

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