In the 1870s, surgery was a crude affair performed on the patient's kitchen table. In the frontier town of Rochester, Minnesota, Dr. W. W. Mayo brought his young sons, Will and Charlie, to assist him with operations. Fifty years later, Rochester became a medical mecca as the Mayo brothers were established as world-class surgeons. With a firm belief in sharing information and learning from others, the Mayo brothers proved the benefits of cooperation in a jealously competitive field, and accomplished more than any single colleague of their time. Emily Crofford gives a vivid account of the Mayos' meteoric rise to fame and their contributions as pioneers on the frontier of modern surgery.