ISBN-10:
1603273344
ISBN-13:
9781603273343
Pub. Date:
03/26/2009
Publisher:
Springer-Verlag New York, LLC
Functional Selectivity of G Protein-Coupled Receptor Ligands: New Opportunities for Drug Discovery / Edition 1

Functional Selectivity of G Protein-Coupled Receptor Ligands: New Opportunities for Drug Discovery / Edition 1

by Kim Neve

Hardcover

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Product Details

ISBN-13: 9781603273343
Publisher: Springer-Verlag New York, LLC
Publication date: 03/26/2009
Series: The Receptors
Edition description: 2009
Pages: 292
Product dimensions: 6.30(w) x 9.30(h) x 0.80(d)

Table of Contents

Historical Overview of the Concept of Functional Selectivity.- Functional Selectivity: Theoretical Considerations and Future Directions.- Agonist Selective Coupling of G Protein-Coupled Receptors.- Ligand-Selective Receptor Desensitization and Endocytosis.- Selectivity for G protein or Arrestin-Mediated Signaling.- In Vivo Evidence for and Consequences of Functional Selectivity.- Functional Selectivity at Adrenergic Receptors.- Signaling Diversity Mediated by Muscarinic Acetylcholine Receptor Subtypes and Evidence for Functional Selectivity.- Functional Selectivity at Serotonin Receptors.- Functional Selectivity at Dopamine Receptors.- Functional Selectivity at Receptors for Cannabinoids and other Lipids.- Functional Selectivity at Opioid Receptors
Graciela Piñeyro.- Functional Selectivity at non-Opioid Peptide Receptors

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