Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development.
The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others.
- Presents revised and updated information for each chapter on systems
- Contains expanded sections on applied toxicologic pathology
- Includes the essential information necessary to understand toxicologic pathology in an accessible language
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About the Author
Dr. Bolon is Associate Director of the Department of Veterinary Biosciences and the Comparative Pathology and Mouse Phenotyping Shared Resource at The Ohio State University, Columbus, Ohio, USA
• Diplomate American College of Veterinary Pathologists (ACVP)
• Diplomate American Board of Toxicology (ABT)
• Fellow Academy of Toxicological Sciences (ATS)
• Fellow International Academy of Toxicologic Pathology (IATP)
Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicology’s Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPA’s FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathology’s Achievement Award in 2007 and the Midwest Regional Chapter - Society of Toxicology’s Kenneth DuBois Award in 2011.
-Diplomate of the American College of Veterinary Pathologists (ACVP)
-Diplomate of the American Board of Toxicology (ABT)
-Fellow of the International Academy of Toxicologic Pathologists (FIATP)
Professor Rousseaux is a Fellow of the Royal College of Pathology, Diplomate of the American Board of Toxicology, Fellow of the Academy of Toxicological Sciences, and Fellow of the International Academy of Toxicologic Pathology. He is Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceutical, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former president of the Society of Toxicologic Pathology.
Table of Contents
1. Overview of Toxicological Pathology
Part I: Principles of Toxicologic Pathology 2. Biochemical and Molecular Basis of Toxicity 3. Pharmacokinetics&Toxicokinetics 4. Principles of Pharmacodynamics&Toxicodynamics 5. Morphologic Manifesations of Toxic Cell Injury 6. Carcinogenesis: Mechanisms and Manifestation 7. Design of Studies&Risk Management in Toxicologic Pathology
Part II: Systems Toxicologic Pathology 8. Hepatobiliary System 9. Cardiovascular System 10. Muscular System 11. Urinary System 12. Immune System 13. Hematopoietic System 14. Respiratory Tract 15. Digestive Tract 16. Exocrine Pancreas 17. Male Reproductive System 18. Female Reproductive System 19. Mammary Gland 20. Endocrine System 21. Nervous System 22. Special Senses: Ocular Sytem 22b. Special Senses: Auditory System 23. Skeletal System (Bone&Joint) 24. Integumentary System 25. Embryo, Fetus&Placenta