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This book is a summary and proceedings of a symposium sponsored by the Government-University-Industry Research Roundtable and the National Science Foundation. It includes presentations by senior government science policy officials and leading scientists who are directly involved in the research and higher education policy formulation processes in various countries. Included are their assessments of current challenges to their national research systems, descriptions of national strategies for meeting these challenges, and a discussion of options for national research systems in the twenty-first century.