Leading clinical and basic science researchers present the latest molecular and cellular findings on key gut peptides, illuminating their physiology and pathophysiology, as well as highlighting the regulatory mechanisms underlying their action in the intestinal tract. The book focuses on gut peptide physiology and receptor pharmacology, gut processing and receptor biology, and on regulatory mechanisms in the gut, including pancreatic feedback mechanisms. Also included are chapters on the trophic effects of gut peptides on GI and pancreatic cancer; the regulation of gut peptide gene expression; and gastric secretion, especially in diseased states.
Table of ContentsIntroduction. Structure and Function of Gastrointestinal Endocrine Cells, Alison M. J. Buchan. Part I. Biochemistry, Pharmacology, and Receptor Biology. Biosynthesis and Processing of Gastrointestinal Peptide Hormones, Margery C. Beinfeld. Mechanisms that Attenuate Signaling by Regulatory Peptides, Stephan Böhm, Eileen F. Grady, and Nigel W. Bunnett. Cellular and Molecular Targets of Gastrin, Nadya Tarasova. Receptors for Peptides of the VIP/PACAP and PYY/NPY/PP Families, Marc Laburthe, Alain Couvineau, and Thierry Voisin. Part II. Regulatory Mechanisms and Systems. Physiology and Pathophysiology Cholecystokinin: Hormonal and Neurocrine Regulator of Postprandial Gastrointestinal Function, Helen E. Raybould. Effects of Aging on Gut Hormones, Tien C. Ko and James C.Thompson. Gastrointestinal Hormones and Gastrointestinal Cancer Growth, Yan-Shi Guo and Courtney M. Townsend, Jr. Intraluminal Regulatory Peptides and Intestinal Cholecystokinin Secretion, Alan W. Spannagel and Gary M. Green. Neuroendocrine Control of the Exocrine Pancreas, David C. Whitcomb. Neuroendocrine Immune Axis in the Intestine, Sang K.Park and M. Sue O'Dorisio. Neuroendocrine Regulation of Intestinal Peristalsis, J. R. Grider and A. E. Foxx-Orenstein. Pancreatic Polypeptide and Glucose Metabolism, Neal E. Seymour and Dana K. Andersen. Peptide Release from the Upper Small Intestine, Jean-Claude Cuber. Regulation of Gastric Acid Secretion, Wolfgang E. Schmidt and Jerzy B. Bójko . Role of Cholecystokinin in Physiologic and Pathophysiologic Growth of the Pancreas, Craig D. Logsdon. Part III. Gut Peptides. Expression of the Neurotensin/Neuromedin N Gene in the Gut: A Potential Model for Gut Differentiation, B. Mark Evers. Glucose-Dependent Insulinotropic Polypeptide (GIP): Incretin vs Enterogastrone, M. Michael Wolfe, Michael O. Boylan, Timothy J. Kieffer, and Chi-Chuan Tseng. Insulin-Like Growth Factors and Their Receptors and Binding Proteins in the Gastrointestinal System, Yan-Shi Guo, James C.Thompson, and Courtney M.Townsend, Jr. Intestinal Proglucagon-Derived Peptides, Patricia L. Brubaker and Daniel J. DruckerIslet. Amyloid Polypeptide and Adrenomedullin: Novel Peptide Hormones Expressed in the Gastro-Entero-Pancreatic Region, Hindrick Mulder, Bo Ahrén, Eva Ekblad, Samuel Gebre-Medhin, Christer Betsholtz, Johan Sundelin, Gunilla T. Westermark, Per Westermark, and Frank Sundler. Peptide YY, Guillermo Gomez, Vidyavathi Udupi, and George H. Greeley, Jr. Index.